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Biological Activity
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.21 mL | 86.07 mL | 172.15 mL |
0.5 mM | 3.44 mL | 17.21 mL | 34.43 mL |
1 mM | 1.72 mL | 8.61 mL | 17.21 mL |
5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 580.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A21617 |
---|---|
CAS No. | 849550-67-0 |
Formula | C22H22ClF5N6O5 |
M. Wt | 580.89 |
Purity | >98% |
Synonyms | TTI-237 fumarate, TTI237, TTI 237 |
SMILES | C[[email protected]@H](C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13.O=C(O)/C=C/C(O)=O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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