Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Olanzapine-d4 is a deuterium-labeled analog of Olanzapine, serving as a stable isotope for research applications. This compound is primarily utilized in pharmacokinetic studies, enabling precise tracking and analysis of Olanzapine metabolism and activity in biological systems. Its incorporation into experimental designs enhances the understanding of drug interactions and effects in clinical research. -
Stable Isotope
Rhein-13C4 is a stable isotope-labeled form of Rhein, an anthraquinone compound known for its anti-inflammatory, antioxidant, and potential anti-cancer properties. This compound serves as a valuable tool in metabolic tracing and pharmacokinetic studies, enabling researchers to investigate the biochemical pathways and therapeutic effects of Rhein in various biological contexts. Its unique isotopic signature facilitates precise quantification and tracking in biological samples. -
Stable Isotope
Toremifene-d6 citrate is a deuterium-labeled variant of Toremifene citrate, a second-generation selective estrogen-receptor modulator (SERM). It demonstrates significant biological activity by inhibiting the replication of the Ebola virus (EBOV Zaire) and Marburg virus (MARV), with IC50 values of 0.07 μM and 2.6 μM, respectively. This stable isotope can be utilized in research applications involving estrogen receptor signaling and viral pathogenesis studies. -
Stable Isotope
Glycine ethyl ester-13C hydrochloride is a stable isotope-labeled derivative of glycine ethyl ester. This reagent serves as a valuable tool in metabolic studies, providing insights into metabolic pathways and the synthesis of amino acids. It is particularly useful in NMR spectroscopy and tracer studies to track cellular processes involving glycine metabolism. -
Stable Isotope
Ibandronic Acid-d3 sodium is a deuterated form of Ibandronic acid, a potent nitrogen-containing bisphosphonate that primarily targets bone resorption by inhibiting osteoclast activity. This stable isotope is useful in pharmacokinetic studies and metabolic research, enabling detailed investigation of drug dynamics and interactions in various biological systems. The application of Ibandronic Acid-d3 sodium contributes to the understanding of bisphosphonate action in osteoporosis treatment. -
Stable Isotope
Galanthamine-d3 hydrochloride is a deuterium-labeled derivative of Galanthamine, primarily used as a stable isotope. This compound serves as a useful tool in pharmacokinetic studies and metabolic research, enabling the investigation of drug metabolism and distribution. Galanthamine-d3 hydrochloride plays a significant role in understanding the mechanisms of action of acetylcholinesterase inhibitors and their effects on neurological processes. -
Stable Isotope
Ritonavir-13C3 is a stable isotope-labeled derivative of Ritonavir, which primarily acts as an inhibitor of HIV protease. In addition to its role in the treatment of HIV infection and AIDS, Ritonavir-13C3 also demonstrates inhibition of SARS-CoV 3CLpro with an IC50 value of 1.61 μM. This compound is useful in research applications involving metabolic studies and tracking the pharmacokinetics of Ritonavir in biological systems. -
Stable Isotope
(S)-10-Hydroxycamptothecin-d5 is a stable isotope-labeled form of (S)-10-Hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. This compound exhibits significant apoptosis-inducing properties, making it valuable in the study of cancer biology. Its applications extend to research involving hepatoma, gastric carcinoma, colon cancer, and leukemia, enabling detailed investigations into the mechanisms of action and therapeutic potential of topoisomerase I inhibition. -
Stable Isotope
Paroxetine-d4 is a deuterium-labeled derivative of Paroxetine, a selective serotonin reuptake inhibitor (SSRI). This compound is primarily utilized in research to study the pharmacokinetics and metabolic pathways of SSRIs. Known for its antidepressant and anxiolytic properties, Paroxetine also exhibits weak norepinephrine reuptake inhibition, which can induce apoptosis in certain cell types and has been associated with anti-tumor activity. Research applications include investigations into psychiatric disorders such as obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder, as well as the management of chronic pain conditions. -
Stable Isotope
Pantoprazole-d8 is a deuterium-labeled form of Pantoprazole, a potent proton pump inhibitor (PPI) that targets H+/K+-ATPase with an IC50 of 6.8 μM. This compound exhibits significant anti-secretory and anti-ulcer activities, enhancing gastric pH stability. Research applications include investigating the pharmacokinetics of Pantoprazole and its potential synergistic effects with other chemotherapeutic agents, such as Doxorubicin, in tumor growth modulation. -
Stable Isotope
N-Oxide Lidocaine-d10 is a deuterium-labeled derivative of Lidocaine, which primarily targets voltage-gated sodium channels, inhibiting their activity in a complex, use-dependent manner. This compound exhibits significant biological activity, notably reducing the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and subsequently inactivating the MEK/ERK and NF-κB signaling pathways. N-Oxide Lidocaine-d10 is valuable for research into ventricular arrhythmias and related cardiac applications. -
Stable Isotope
Moexipril-d5 is a deuterium-labeled derivative of Moexipril, an orally active non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is valuable for pharmacokinetic studies and metabolic research, particularly in understanding drug metabolism and distribution. It exhibits significant antihypertensive effects and offers insights into the mechanisms of hypertension and heart failure treatments. -
Stable Isotope
Ramipril-d4 is a deuterated form of Ramipril, an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. This stable isotope is utilized in pharmacokinetic studies and metabolic research to track drug metabolism and distribution. Ramipril-d4 serves as a valuable tool in understanding the pharmacodynamics and therapeutic effects of ACE inhibitors in cardiovascular research. -
Stable Isotope
Oxymatrine-d3 is a deuterium-labeled derivative of Oxymatrine, an alkaloid extracted from Sophora flavescens with notable anti-inflammatory, antifibrotic, and antitumor properties. It primarily targets the inhibition of inducible nitric oxide synthase (iNOS) expression and disrupts the TGF-β/Smad signaling pathway. Oxymatrine-d3 is useful in research applications focused on viral pathogenesis, demonstrating efficacy in inhibiting the replication of minute virus of canines (MVC) and reducing associated viral gene expression while mitigating apoptosis resulting from viral infections. -
Stable Isotope
2-Deoxy-D-glucose-13C6 is a stable isotope-labeled analog of 2-deoxy-D-glucose. It functions as a competitive inhibitor of glucose metabolism by specifically inhibiting glycolysis through its interaction with hexokinase. This reagent is valuable for metabolic studies, tracing glucose pathways, and investigating cellular energy metabolism in various research applications. -
Stable Isotope
(E/Z)-Capsaicin-d3 is a deuterated form of (E/Z)-Capsaicin, serving as a stable isotope for tracer studies. This compound can be utilized in various research applications including pharmacokinetics and metabolic studies, allowing for the analysis of capsaicin's biological effects and mechanisms. Its isotopic labeling facilitates advanced detection techniques in both in vitro and in vivo experiments. -
Stable Isotope
Sodium propionate-13C-1 is a stable isotope-labeled derivative of sodium propionate, functioning primarily as a short-chain fatty acid. It is synthesized by intestinal bacteria through dietary fiber metabolism and exhibits multiple biological activities, including increased PPAR-γ expression and inhibition of NF-κB activation, COX-2 expression, and NO production. Additionally, sodium propionate induces apoptosis and autophagy while demonstrating neuroprotective, antioxidant, and anti-inflammatory properties. Its applications span various research areas, including spinal cord injury, Alzheimer's disease, and glioblastoma, presenting potential avenues for therapeutic exploration. -
Stable Isotope
Sunitinib-d4 is a deuterated form of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor. It exhibits potent inhibitory activity against VEGFR2 and PDGFRβ, with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d4 effectively impedes the autophosphorylation of Ire1α, thereby blocking RNase activation. This stable isotope is valuable for studies involving drug metabolism and pharmacokinetics, allowing for precise tracking and quantification in biological research. -
Isotope-Labeled Compound
Epoxiconazole-d4 is a deuterium-labeled analog of Epoxiconazole, a systematic demethylation inhibitor targeting the Ergosterol biosynthesis pathway. This compound demonstrates potent antifungal activity against carbendazim-resistant and phenamacril-resistant fungal isolates, making it valuable for the control of various crop diseases. Its isotope-labeled form facilitates advanced research applications in pesticide metabolism and environmental fate studies. -
Stable Isotope
Adenosine-15N is a stable isotope-labeled form of adenosine, specifically labeled with nitrogen-15. This endogenous autacoid interacts with four G protein-coupled receptors: A1, A2A, A2B, and A3, playing a critical role in various physiological processes. Researchers utilize Adenosine-15N to investigate cellular mechanisms, including neuronal signaling, vascular function, and the modulation of immune response, enabling advanced studies in cellular biology and pharmacology. -
Stable Isotope
Pomalidomide-13C5 is a stable isotope-labeled derivative of Pomalidomide, a third-generation immunomodulatory agent that functions as a molecular glue. This compound interacts specifically with the E3 ligase cereblon, leading to the targeted degradation of key Ikaros transcription factors. Pomalidomide-13C5 is valuable for research applications involving protein degradation pathways, immunomodulation studies, and tracing metabolic processes in cellular models. -
Stable Isotope
Eltrombopag-d3 is a deuterium-labeled variant of Eltrombopag, a nonpeptide agonist of the thrombopoietin receptor. This compound exhibits thrombopoietic activity and is utilized in research related to chronic immune thrombocytopenia characterized by low blood platelet counts. Additionally, Eltrombopag has demonstrated efficacy in cardiovascular research and possesses significant inhibitory effects against multidrug-resistant Staphylococcus aureus. It is also known to induce apoptosis in hepatocellular carcinoma cells, making it a valuable tool for cancer research studies. -
Stable Isotope
Urea-13C,15N is a stable isotope-labeled form of urea, incorporating both 13C and 15N isotopes. It serves as a potent protein denaturant, affecting protein structure through various mechanisms, and is utilized in metabolic studies to evaluate renal function through blood urea nitrogen (BUN) levels. Additionally, Urea-13C,15N finds applications in chemical research as a nitrogen source in fertilizers and as a critical component in various industrial processes. -
Stable Isotope
Lenalidomide-d4 is a deuterium-labeled derivative of Lenalidomide, functioning as a stable isotope for advanced chemical research. As an orally active immunomodulator, Lenalidomide targets the cereblon (CRBN) ubiquitin E3 ligase, leading to the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3. This activity is particularly relevant in the context of mature B-cell lymphomas, including multiple myeloma, where Lenalidomide-d4 has been shown to inhibit tumor growth and promote IL-2 release from T cells. This reagent is suitable for studies in drug mechanisms and development within the field of oncology. -
Stable Isotope
Cladribine-15N is a nitrogen-15 labeled analog of Cladribine (2-Chloro-2′-deoxyadenosine), which acts as an inhibitor of adenosine deaminase. This compound plays a crucial role in inhibiting DNA synthesis, thereby preventing the repair of damaged DNA and influencing DNA methylation processes. It exhibits significant anti-lymphoma activity and is applicable in research involving various hematologic malignancies and multiple sclerosis. The stable isotope labeling allows for advanced analytical techniques in biological studies. -
Stable Isotope
Quinolinic acid-13C7 is a stable isotope-labeled form of quinolinic acid, an endogenous metabolite of tryptophan. This compound acts as an N-methyl-D-aspartate (NMDA) receptor agonist, enhancing glutamate release, promoting reactive oxygen species generation, and activating nitric oxide synthase. These actions can lead to increased nitric oxide production, calcium ion influx, and consequent neuronal apoptosis, making this reagent valuable for studies in neurobiology, metabolism, and neurodegenerative diseases. -
Stable Isotope
2,4-D-d3 is a deuterium-labeled derivative of 2,4-D (2,4-Dichlorophenoxyacetic acid), a selective systemic herbicide. As a plant growth regulator, 2,4-D primarily targets meristematic tissues, leading to uncontrolled growth. This compound disrupts DNA and protein synthesis, inhibiting normal plant growth and development. 2,4-D-d3 is utilized in research applications for studying herbicide metabolism and plant hormonal responses. -
Stable Isotope
Candesartan Cilexetil-d11 is a deuterium-labeled derivative of Candesartan Cilexetil, targeting angiotensin II receptors. This compound demonstrates biological activity in ameliorating pulmonary fibrosis and has been shown to possess antiviral properties, as well as promoting skin wound healing. Candesartan Cilexetil-d11 is useful for pharmacokinetic studies and research involving hypertension. -
Stable Isotope
Octreotide-d8 is a deuterium-labeled analog of the somatostatin receptor agonist, Octreotide. It selectively binds to somatostatin receptor subtypes 2, 3, and 5, enhancing Gi signaling and decreasing intracellular cAMP levels. Octreotide-d8 exhibits notable antitumor activity and is instrumental in apoptosis studies, making it a valuable tool for research on acromegaly and related diseases. -
Stable Isotope
Lidocaine-d6 is a deuterated form of Lidocaine, serving as a stable isotope for metabolic studies and analytical applications. Lidocaine primarily targets sodium channels, exhibiting voltage-dependent inhibition. In cancer research, it has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145, which leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. This compound is also relevant for studies on ventricular arrhythmias, providing insights into cardiac electrophysiology. -
Stable Isotope
Deracoxib-d4 is a deuterium-labeled derivative of Deracoxib, a selective COX-2 inhibitor primarily employed in veterinary medicine. By inhibiting the COX-2 enzyme, Deracoxib-d4 effectively reduces prostaglandin synthesis, thus controlling pain and inflammation following soft tissue surgeries in dogs. This compound demonstrates minimal COX-1 inhibition, lowering the likelihood of gastrointestinal complications. Additionally, Deracoxib-d4 exhibits anti-tumor properties, inducing cell cycle arrest and apoptosis in various canine tumors, including osteosarcoma and transitional cell carcinoma of the bladder. -
Stable Isotope
Carbocisteine-13C3-1 is a stable isotope-labeled derivative of Carbocisteine, primarily targeting mucolytic activity. This compound is known to inhibit the phosphorylation of NF-κB p65 and ERK1/2, modulating the interplay between Nrf2 and HO-1. Additionally, Carbocisteine exhibits apoptotic inhibition properties. It is widely employed in research related to chronic obstructive pulmonary disease (COPD) and other respiratory conditions. -
Stable Isotope
Everolimus-13C2,d4 is a stable isotope-labeled derivative of Everolimus, a potent and selective inhibitor of mTOR1. By binding to FKBP-12, Everolimus forms an immunosuppressive complex that effectively inhibits tumor cell proliferation while promoting apoptosis and autophagy. This compound is valuable for research applications in cancer therapy and immunosuppression studies, facilitating tracking and quantification in metabolic and pharmacokinetic investigations. -
Stable Isotope
Zoledronic acid-d3 is a deuterium-labeled analogue of Zoledronic acid, a third-generation bisphosphonate. This compound exerts potent anti-resorptive activity by inhibiting osteoclast differentiation and inducing apoptosis in these cells. Additionally, Zoledronic acid demonstrates anti-cancer effects, making it valuable for research on bone metabolism and cancer therapies. It serves as a stable isotope for various analytical applications in biological and pharmacological studies. -
Stable Isotope
Fludioxonil-13C3 is a stable isotope-labeled version of Fludioxonil, a phenylpyrrole fungicide known for its oral activity against Sclerotinia sclerotiorum. It exhibits biological activities that promote tumor growth and metastasis, as well as induce cardiac toxicity. Research applications include studies on cytoskeletal disruption, DNA damage, and apoptosis in glioma cells, making it a valuable tool for investigating the mechanisms of action in cellular biology and oncology. -
Stable Isotope
Avobenzone-d3 is a deuterium-labeled derivative of Avobenzone, a dibenzoylmethane compound utilized primarily as a UV filter in sunscreens, specifically for UVA protection. This compound has been identified as an endocrine disruptor, directly binding to estrogen receptor β and acting as an estrogen agonist. Avobenzone-d3 is valuable in research applications investigating the mechanisms of photoprotection and endocrine disruption, facilitating studies on the biological effects of commonly used sunscreen ingredients. -
Stable Isotope
Alternariol-d2 is a deuterium-labeled derivative of the mycotoxin alternariol, primarily targeting topoisomerase I and II. This compound demonstrates key biological activities, including weak estrogenic and androgenic effects, along with the ability to induce apoptosis, arrest the cell cycle, and suppress innate immune responses. It is relevant for research applications involving genotoxicity, mutagenicity, and its potential role as an endocrine disruptor, making it a valuable tool for studying the effects of mycotoxins in biochemical and pharmacological investigations. -
Stable Isotope
Sildenafil-d5 is a deuterium-labeled derivative of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, exhibiting an IC50 of 5.22 nM. This stable isotope is utilized in pharmacokinetic studies and metabolism research to trace and quantify the parent compound and its metabolites. Its application is essential in understanding the dynamics of Sildenafil's action and its therapeutic efficacy in various contexts. -
Stable Isotope
Rabeprazole-13C,d3 is a deuterated form of Rabeprazole, a second-generation proton pump inhibitor (PPI) that irreversibly inhibits gastric H+/K+-ATPase. This compound is known to induce apoptosis and has been identified as an inhibitor of uridine nucleoside ribohydrolase (UNH) with an IC50 value of 0.3 μM. Rabeprazole-13C,d3 is utilized in research focused on gastric ulcerations and gastroesophageal reflux disease, facilitating the study of drug metabolism and action in biological systems. -
Stable Isotope
Amiloride-15N3 is a stable isotope-labeled derivative of Amiloride, specifically incorporating nitrogen-15. This compound functions as an inhibitor of the epithelial sodium channel (ENaC) and the urokinase-type plasminogen activator receptor (uPA). Additionally, Amiloride is recognized for its capacity to block the polycystin-2 (PC2; TRPP2) channel, making it a valuable tool in studying ion transport, cardiovascular biology, and renal function. -
Stable Isotope
Cyclamic acid-d4 sodium is a stable isotope-labeled derivative of cyclamic acid sodium, commonly utilized as a sweetener. This compound exhibits toxicity towards osteoblasts, inhibiting cell proliferation and inducing apoptosis, ultimately reducing cell mineralization. In vitro studies demonstrate that cyclamic acid sodium can cause focal necrosis in bladder tissue, potentially promoting bladder cancer; however, some research indicates that low doses may not exhibit carcinogenic effects. Furthermore, cyclamic acid sodium does not significantly influence insulin and glucagon secretion triggered by arginine, making it a relevant reagent for studying metabolic pathways and toxicological effects. -
Stable Isotope
4-Oxofenretinide-d4 is a deuterium-labeled derivative of 4-Oxofenretinide, specifically designed for use as a stable isotope in research applications. 4-Oxofenretinide is recognized for its ability to inhibit cell growth in various cancer cell lines, including ovarian, breast, and neuroblastoma. It facilitates the accumulation of cells in the G2-M phase of the cell cycle and triggers apoptosis in cancer cells via activation of caspase-9. This reagent is essential for studies focusing on cancer biology and therapeutic development. -
Stable Isotope
Lacidipine-d10 is a deuterated analog of Lacidipine, a potent L-type calcium channel blocker. This stable isotope is primarily used in pharmacokinetic studies and metabolic research to trace the disposition of Lacidipine in biological systems. Its distinctive deuterium labeling enables enhanced analytical precision in mass spectrometry applications. -
Stable Isotope
Nerol-d2 is a deuterated form of Nerol, a naturally occurring compound found in neroli oil. It serves as a stable isotope for metabolic studies and tracer experiments. Nerol-d2 is known to induce mitochondrial dysfunction and promote apoptosis through the elevation of calcium ions (Ca2+) and reactive oxygen species (ROS). Additionally, it exhibits antifungal activity, making it relevant in various biological research applications. -
Stable Isotope
Propanoic acid-13C3 is a stable isotope-labeled derivative of propanoic acid, targeting metabolic pathways involving short-chain fatty acids. This compound demonstrates significant biological activity by enhancing PPAR-γ expression, inhibiting NF-κB activation, and downregulating COX-2 and nitric oxide production. Additionally, propanoic acid-13C3 has been shown to induce apoptosis and autophagy, display neuroprotective effects, and exhibit anti-inflammatory properties. Its applications extend to research in spinal cord injury, Alzheimer's disease, and glioblastoma therapy, making it a valuable tool for metabolic and neurological studies. -
Stable Isotope
Citric acid-13C2 is a stable isotope-labeled form of citric acid, primarily used as a tracer in metabolic studies. This compound plays a crucial role in cellular processes, inducing apoptosis and leading to cell cycle arrest in HaCaT cells at the G2/M and S phases. Additionally, citric acid is known to promote oxidative damage in liver tissues by reducing antioxidative enzyme activities. Its properties as an acidulant, emulsifier, and buffering agent make it valuable across various industrial applications, including food preservation and formulation optimization in chemical research. -
Stable Isotope
Avobenzone-13C,d3 is a stable isotope-labeled form of Avobenzone, a dibenzoylmethane derivative. This compound functions primarily as a UVA filter in sunscreen formulations, providing effective skin photoprotection. Additionally, Avobenzone serves as an endocrine disruptor by binding to the estrogen receptor β and acting as an estrogen agonist. This reagent is valuable for research on hormonal activity and photoprotection mechanisms. -
Stable Isotope
p,p'-DDD-d8 is a deuterium-labeled derivative of p,p'-DDD, an organochlorine insecticide and significant metabolite of p,p'-DDT. This compound acts as an agonist for estrogen receptors α (ERα) and β (ERβ), influencing cellular pathways linked to DNA damage, apoptosis, and necrosis in peripheral blood. Additionally, p,p'-DDD has been shown to promote cell proliferation in SKBR3 cells and activate the AP-1 transcription factor. Its effects on sleep patterns, particularly reducing sleep times induced by barbiturates and steroids in rat models, highlight its potential relevance in pharmacological studies. -
Stable Isotope
Hexestrol-d4 is a deuterium-labeled synthetic estrogen that selectively binds to estrogen receptors alpha (ERα) and beta (ERβ) with a Ki of 0.06 nM. This compound serves as a valuable stable isotope standard for studies investigating estrogen deficiency-related diseases. Additionally, it has applications in animal research, particularly in evaluating its effects on livestock weight gain. -
Stable Isotope
Lidocaine-d6 hydrochloride is a deuterium-labeled derivative of Lidocaine, primarily targeting voltage-gated sodium channels. It exhibits significant biological activity by inhibiting the growth, migration, and invasion of gastric carcinoma cells through the up-regulation of miR-145 and the subsequent inactivation of the MEK/ERK and NF-κB signaling pathways. This reagent is vital for research in electrophysiological studies and cancer biology, particularly in investigating sodium channel modulation and tumorigenesis mechanisms.
