Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Mandelic acid-2,3,4,5,6-d5 is a deuterium-labeled variant of mandelic acid, an alpha-hydroxycarboxylic acid. This stable isotope serves as a valuable tool in tracing studies and metabolic research. Mandelic acid demonstrates antimicrobial properties and has applications in the study of urinary tract infections and vaginal trichomoniasis. Additionally, it is known for its high sperm-immobilizing activity while minimizing vaginal irritation, making it relevant for reproductive health research. -
Stable Isotope
Nonanoic acid-d2 is the deuterium-labeled derivative of nonanoic acid, a saturated fatty acid comprising nine carbon atoms. This compound plays a critical role in metabolic studies and tracing experiments due to its stable isotope labeling. Research indicates that nonanoic acid exhibits significant antibacterial properties, reduces bacterial translocation, and enhances the secretion of porcine β-defensins 1 and 2, making it a valuable tool in studies of intestinal health and antimicrobial peptide function. -
Stable Isotope
Thymol-d13 is a deuterated form of Thymol, a key monoterpene phenol primarily found in essential oils from the Lamiaceae family as well as various other plant families, including Verbenaceae, Scrophulariaceae, Ranunculaceae, and Apiaceae. This stable isotope is utilized in research to trace pathways and quantify metabolites in biological systems. Thymol exhibits notable biological activities, including antioxidant, anti-inflammatory, antibacterial, and antifungal properties, making it relevant for studies in pharmacology and biochemistry. -
Stable Isotope
Octacosane-d58 is the deuterated form of octacosane, a long-chain hydrocarbon with antibacterial properties. This stable isotope is valuable for studies investigating the metabolic pathways and biological activities of octacosane. Notably, octacosane exhibits considerable cytotoxicity against murine melanoma B16F10-Nex2 cells and provides protective effects in subcutaneous melanoma models. Additionally, it demonstrates larvicidal activity against the mosquito Culex quinquefasciatus, with an LC50 of 7.2 mg/L, making it a useful compound for research in both cancer biology and pest control. -
Stable Isotope
Vitamin D3-d7 is a deuterium-labeled form of Vitamin D3 (Cholecalciferol), enabling precise tracking in metabolic studies. It is known to promote cell differentiation and inhibit the proliferation of cancer cells, making it a valuable tool in cancer research. This stable isotope is particularly useful for pharmacokinetic studies and the investigation of vitamin D metabolism in biological systems. -
Stable Isotope
Benzothiazole-d4 is a stable isotope-labeled form of Benzothiazole, a naturally occurring heterocyclic compound. This reagent is widely utilized in biological research due to its diverse activities, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral properties. Benzothiazole-d4 is particularly valuable for tracing studies and metabolic profiling in various biological systems. -
Stable Isotope
Butylparaben-d4 is a deuterium-labeled derivative of Butylparaben, an organic compound recognized for its effective antimicrobial properties. This reagent is primarily utilized as a stable isotope in chemical research, allowing for the tracing and quantification of Butylparaben in various applications, including cosmetics, pharmaceuticals, and food products. Its stability and unique labeling make it essential for studying the dynamics of antimicrobial preservation and understanding the compound's behavior in complex matrices. -
Stable Isotope
Ethylparaben-d4 is a deuterium-labeled analog of ethylparaben, primarily utilized as a stable isotope standard in analytical chemistry. This compound serves as an internal standard in mass spectrometry and other analytical techniques, facilitating precise quantification and analysis of ethylparaben and its metabolites in biological samples. Its unique isotopic signature enhances the accuracy of trace-level detection and study of paraben-related biological activity in various research applications. -
Stable Isotope
Robenidine-d8 hydrochloride is a deuterium-labeled analogue of Robenidine hydrochloride, primarily utilized as a stable isotope in research. As an effective anticoccidial agent, it exhibits biological activity against Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE), with MIC50 values of 8.1 µM and 4.7 µM, respectively. This compound is valuable for studies investigating coccidiosis and antibiotic resistance in bacterial pathogens. -
Stable Isotope
Lauric acid-d2 is a deuterium-labeled form of lauric acid, a medium-chain fatty acid known for its potent bactericidal activity. It exhibits effective antibacterial properties against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, with EC50 values of 2, 6, and 4 μg/mL, respectively. This stable isotope is valuable for research applications in microbiology and lipid metabolism studies, enabling the elucidation of fatty acid metabolism and the investigation of antimicrobial mechanisms. -
Stable Isotope
(±)-Leucine-d7 is a deuterium-labeled form of (±)-Leucine, a proteinogenic amino acid. This stable isotope is useful for tracing pathways in metabolic studies, particularly in the analysis of amino acid metabolism and protein synthesis. (±)-Leucine exhibits inhibitory effects on the growth of Escherichia coli HfrH, making it relevant for research involving bacterial cultures and metabolic inhibition. -
Stable Isotope
Triclocarban-d4 is the deuterated form of Triclocarban, a triclocarban compound functioning as a broad-spectrum antibacterial agent. This stable isotope is utilized in various applications, including the formulation of personal care products such as soaps, skin creams, and deodorants. Triclocarban has been identified as a potential endocrine disruptor, capable of affecting androgen and estrogen activity, thereby influencing hormone-mediated biological processes in research studies. -
Isotope-Labeled Compounds
Ethyl acetoacetate-d3 is a deuterium-labeled isotopologue of ethyl acetoacetate. This ester serves as a valuable intermediate in the synthesis of diverse organic compounds. Additionally, ethyl acetoacetate demonstrates bioactivity as an inhibitor of bacterial biofilm formation, making it useful for research applications in microbiology and pharmaceutical development. -
Stable Isotope
Nonanoic acid-d3 is a deuterated analog of nonanoic acid, a naturally occurring saturated fatty acid comprising nine carbon atoms. This stable isotope serves as a useful tracer in metabolic studies and is valuable in research focusing on lipid metabolism, fatty acid absorption, and microbial interactions. Nonanoic acid has been shown to reduce bacterial translocation, enhance antibacterial activity, and increase the secretion of important antimicrobial peptides, specifically porcine β-defensins 1 and 2. -
Stable Isotope
Levulinic acid-d5 is a deuterium-labeled derivative of levulinic acid, primarily used as a stable isotope in chemical research. This compound serves as an important precursor for the synthesis of biofuels, particularly ethyl levulinate, enabling studies on metabolic pathways and the mechanisms of biofuel production. Its unique isotopic labeling facilitates advanced analytical techniques, including mass spectrometry and NMR, making it a valuable tool for researchers in the field of sustainable energy and organic synthesis. -
Stable Isotope
Rac cis-Moxifloxacin-d4 hydrochloride is a deuterated form of the antibiotic moxifloxacin, specifically designed for use as a stable isotope. This compound retains the properties of moxifloxacin, an 8-methoxyquinolone antimicrobial that targets bacterial infections, including acute bacterial sinusitis and pneumonia. Its stable isotope labeling is beneficial for pharmacokinetic studies, metabolic tracking, and the development of analytical techniques in medicinal chemistry. -
Stable Isotope
Clindamycin Hydrochloride-13C,d3 is a stable isotope-labeled form of Clindamycin hydrochloride, incorporating deuterium and 13C. As a semisynthetic lincosamide antibiotic, it inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit. This reagent is valuable for studying drug metabolism, pharmacokinetics, and antibiotic resistance in various biological research applications. -
Stable Isotope
Sulfadoxine-d4 is a deuterium-labeled derivative of Sulfadoxine, a long-acting sulfonamide antibiotic. It primarily targets dihydropteroate synthase, inhibiting folate synthesis in bacterial cells. Due to its mechanism of action, Sulfadoxine-d4 demonstrates significant antibacterial activity and is employed in research focused on respiratory and urinary tract infections, as well as malaria. Additionally, it has been shown to inhibit HIV replication in peripheral blood mononuclear cells, making it a valuable tool for studies in antiviral research. -
Stable Isotope
Raja 42-d10 is a deuterated form of the gamma-lactam antibiotic Raja 42, designed for studied isotopic labeling applications. This stable isotope exhibits potent antibacterial activity against a range of bacteria, including both Gram-positive and Gram-negative strains, with notable efficacy against C. difficile. Raja 42-d10 is essential for research involving metabolic studies, pharmacokinetics, and the elucidation of mechanistic pathways in bacterial infections. -
Stable Isotope
Sulfamonomethoxine-13C6 is a stable isotope-labeled derivative of the sulfonamide antibiotic sulfamonomethoxine, primarily known for its role in veterinary medicine. This compound functions as a dihydropteroate synthetase inhibitor, effectively disrupting folic acid synthesis and exhibiting antibacterial properties. It serves as a valuable tool in biochemical research, particularly in studies involving antibiotic efficacy and metabolic pathways. -
Stable Isotope
Deruxtecan-d4 is a deuterium-labeled derivative of Deruxtecan, a potent antibody-drug conjugate (ADC) linker. This stable isotope serves as a valuable tool for tracing and quantification in biological studies. Its primary applications include the synthesis of DS-8201 and U3-1402, facilitating research on targeted cancer therapies and drug delivery mechanisms. -
Stable Isotope
Deruxtecan-d4-1 is a deuterium-labeled derivative of Adenosine Deruxtecan, serving as a stable isotope for research applications. This compound features an ADC drug-linker conjugate composed of the DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker. It is primarily utilized in the synthesis of DS-8201 and U3-1402, facilitating studies in targeted cancer therapies and drug development. -
Stable Isotope
Deruxtecan-d6 is a stable isotope-labeled analog of Deruxtecan. This compound is utilized primarily in pharmacokinetic studies to accurately track the behavior of the drug in biological systems. By employing deuterium labeling, researchers can enhance the precision of their analyses in drug metabolism and efficacy research. -
Stable Isotope
Doxofylline-d6 is a deuterium-labeled form of Doxofylline, an adenosine A1 receptor antagonist that also demonstrates phosphodiesterase IV inhibition. This stable isotope is valuable for various research applications, including pharmacokinetic studies, mechanism of action investigations, and metabolic pathway analysis. Its unique labeling allows for enhanced tracking and quantification in complex biological systems. -
Stable Isotope
Tadalafil-d3 is a deuterated derivative of Nortadalafil, a well-known phosphodiesterase type 5 (PDE5) inhibitor. This stable isotope-labeled compound is utilized in pharmacokinetic studies to trace the metabolism and distribution of Tadalafil in biological systems. Its primary applications include drug development and pharmacological research, particularly in understanding mechanisms associated with erectile dysfunction and pulmonary arterial hypertension. -
Stable Isotope
Dipyridamole-d20 is a deuterium-labeled form of Dipyridamole, a potent phosphodiesterase inhibitor. Its primary mechanism involves the inhibition of adenosine uptake and metabolism by erythrocytes and vascular endothelial cells. This stable isotope-labeled compound is valuable for research applications in pharmacokinetics, metabolic studies, and mechanisms of action involving adenosine pathways in cardiovascular biology. -
Stable Isotope
Roflumilast-d4 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound exhibits potent inhibitory activity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, demonstrating its specificity as it does not impact PDE1, PDE2, PDE3, or PDE5 isoenzymes across various cell types. Roflumilast-d4 is primarily used as a stable isotope internal standard in pharmacokinetic studies and drug metabolism research. -
Stable Isotope
Roflumilast-d4 N-Oxide is a deuterium-labeled analog of Roflumilast, a selective inhibitor of phosphodiesterase 4 (PDE4). It demonstrates high potency with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while sparing the activity against PDE1, PDE2, PDE3, and PDE5 isoenzymes. This compound is valuable for pharmacokinetic studies and metabolic profiling in chemical research related to inflammatory diseases and respiratory conditions. -
Stable Isotope
Nor-Acetildenafil-d8 is a deuterated derivative of Nor-Acetildenafil, targeting phosphodiesterase inhibition. This stable isotope compound is valuable for metabolic studies and pharmacokinetic analyses involving Acetildenafil derivatives. Its unique labeling enables precise tracking and quantification in biological systems, enhancing research applications in drug development and pharmacodynamics. -
Stable Isotope
Acetildenafil-d8 is a deuterium-labeled derivative of Acetildenafil, which acts as an inhibitor of phosphodiesterase 5 (PDE5). This stable isotope is utilized in pharmacokinetic studies to trace metabolic pathways and investigate the pharmacological properties of PDE5 inhibitors. Its application in research enables a deeper understanding of drug metabolism and the effects of deuteration on biological activities. -
Stable Isotope
Udenafil-d7 is a deuterium-labeled analogue of Udenafil, a selective and potent inhibitor of phosphodiesterase type 5 (PDE5). This stable isotope enhances the study of Udenafil's pharmacokinetics and metabolism through isotopic labeling techniques. Udenafil-d7 is primarily used in research related to erectile dysfunction and serves as a valuable tool for elucidating the molecular mechanisms underlying PDE5 inhibition. -
Stable Isotope
N-Desmethyl Sildenafil-d8 is a deuterium-labeled form of N-Desmethyl Sildenafil, a significant metabolite of Sildenafil. This compound acts primarily as a potent inhibitor of phosphodiesterase type 5 (PDE5), which plays a critical role in regulating nitric oxide signaling pathways. N-Desmethyl Sildenafil-d8 is useful in pharmacokinetic studies and metabolic research, providing insights into the metabolism and biological activity of Sildenafil in various biological systems. -
Stable Isotope
Xanthoanthrafil-d3 is a deuterium-labeled derivative of Xanthoanthrafil, a selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 3.95 ng/mL. This reagent is primarily utilized in studies related to erectile dysfunction, facilitating research on PDE5 inhibition and its physiological implications. The stable isotope labeling enhances the compound's tracing capabilities in biochemical studies, making it a valuable tool for researchers investigating the pharmacodynamics and pharmacokinetics of PDE5 inhibitors. -
Stable Isotope
Roflumilast-d3 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. It exhibits high specificity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while showing no inhibition on PDE1, PDE2, PDE3, or PDE5 isoenzymes. This stable isotope is valuable for research applications involving the study of PDE4-dependent signaling pathways and drug metabolism. -
Stable Isotope
Ibudilast-d7 is a deuterium-labeled derivative of Ibudilast, a selective phosphodiesterase (PDE) inhibitor that modulates cyclic AMP levels. This compound exhibits notable platelet anti-aggregatory effects and is relevant in asthma research due to its inhibitory impact on tracheal smooth muscle contractility. Furthermore, Ibudilast is investigated for its potential neuroprotective and anti-dementia properties, particularly in countering neurotoxicity associated with activated microglia. -
Stable Isotope
Ibudilast-d7-1 is a stable isotope-labeled derivative of Ibudilast, a known phosphodiesterase (PDE) inhibitor that modulates cyclic AMP levels. It exhibits platelet anti-aggregatory properties and is utilized in research concerning asthma, particularly for its inhibitory effects on tracheal smooth muscle contraction. Additionally, Ibudilast has potential neuroprotective effects and may serve as an anti-dementia agent by mitigating neurotoxicity in activated microglia. -
Stable Isotope
Vardenafil-d5 is a deuterium-labeled derivative of Vardenafil, a potent and selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It exhibits high selectivity for PDE5 over other phosphodiesterases, including PDE1 (180 nM) and PDE6 (11 nM). By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil-d5 effectively elevates cGMP levels. This reagent is valuable for research applications related to erectile dysfunction. -
Stable Isotope
Milrinone-d3 is a deuterium-labeled derivative of Milrinone, primarily targeting phosphodiesterase 3 (PDE3). This compound functions as both an inotropic agent and a vasodilator, enhancing cardiac contractility and promoting vascular relaxation. Milrinone-d3 is valuable for studies involving drug metabolism, pharmacokinetics, and the mechanistic exploration of PDE3 inhibition in cardiovascular research. -
Stable Isotope
Flavoxate-d5 is a deuterated analog of Flavoxate, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and analytical chemistry to trace metabolic pathways, as well as in the investigation of drug interactions. Its unique isotopic labeling facilitates higher precision in mass spectrometry applications, enhancing the understanding of Flavoxate's biological activity and pharmacological profile. -
Stable Isotope
Vinpocetine-d5 is a deuterium-labeled derivative of Vinpocetine, which primarily inhibits voltage-gated sodium channels. It serves as a phosphodiesterase (PDE) inhibitor, effectively disrupting NF-κB-dependent inflammatory responses by directly targeting the IκB kinase complex (IKK), with an IC50 of 17.17 μM in a cell-free system. This compound is valuable in research related to cerebrovascular disorders and inflammation, enabling the tracking and analysis of Vinpocetine's biological effects in various applications. -
Stable Isotope
Crisaborole-d4 is a deuterium-labeled analog of Crisaborole, a selective inhibitor of phosphodiesterase 4 (PDE4). This compound exhibits potent pharmacological activity, demonstrated by its ability to inhibit PDE4 with an IC50 of 0.49 μM, leading to reduced cytokine release. Crisaborole-d4 can be utilized in biochemical research to study PDE4-related pathways and the role of cyclic AMP in inflammation and immune responses. -
Stable Isotope
Avanafil-13C,d3 is a stable isotope-labeled analog of Avanafil, incorporating both carbon-13 and deuterium isotopes. This compound is designed for use in pharmacokinetic studies and metabolic research, allowing for the precise tracking of compound distribution and metabolism in biological systems. Its stable isotopic labeling enhances the accuracy of analytical methods, facilitating detailed investigations into the pharmacodynamics and biochemical pathways associated with Avanafil. -
Stable Isotope
Triflusal-d3 is a deuterated derivative of Triflusal that serves as a stable isotope for analytical research. It functions as a dual inhibitor of Cyclooxygenase-1 (COX-1) and cAMP phosphodiesterase, demonstrating significant anti-inflammatory properties by inhibiting platelet aggregation and prostaglandin synthesis in ischemic tissues. Triflusal-d3 also enhances neutrophil nitric oxide production and promotes endothelial nitric oxide synthase (eNOS) expression. Its applications extend to the study of thromboembolic and ischemic cardiovascular diseases, as well as Alzheimer's disease models, providing insights into neurological and vascular pathologies. -
Stable Isotope
Exatecan-d5 mesylate is a deuterium-labeled derivative of Exatecan mesylate, functioning as a selective DNA topoisomerase I inhibitor. With an IC50 value of 2.2 μM, it effectively interferes with DNA replication and transcription processes. This reagent is valuable for cancer research, particularly in studies evaluating the mechanisms of action and resistance related to topoisomerase I-targeted therapies. -
Stable Isotope
Paclitaxel-d5 is a deuterium-labeled derivative of Paclitaxel, a potent antineoplastic agent that promotes the stabilization of tubulin polymerization. This stable isotope variant is primarily utilized in pharmacokinetic studies to trace the metabolism and distribution of Paclitaxel in biological systems. Its application is essential for understanding the compound's therapeutic dynamics and potential interactions in oncology research. -
Stable Isotope
Exatecan Intermediate 1-d5 is a deuterium-labeled derivative of Exatecan Intermediate 1, designed for use as a stable isotope in various biochemical studies. This compound serves as a valuable tool in pharmacokinetic and metabolic research, allowing for enhanced tracking of drug metabolism and distribution in biological systems. Its isotopic labeling aids in quantitative analysis and helps elucidate molecular interactions, making it a crucial reagent in the investigation of antitumor agents and related therapeutics. -
Stable Isotope
D-Psicose-d is a deuterium-labeled form of D-Psicose, which serves as a stable isotope for research applications. This rare sugar is known for its oral bioactivity and demonstrates inhibitory effects on p38-MAPK phosphorylation and MCP-1 expression. D-Psicose also modulates the AGEs/RAGE/NF-κB signaling pathway, offering protective effects on pancreatic β-islets and improving metabolic conditions such as hyperglycemia and non-alcoholic fatty liver disease induced by high-fat diets. -
Stable Isotope
Fumaric acid-13C2 is a stable isotope-labeled version of fumaric acid, an unsaturated dicarboxylic acid involved in the citric acid cycle. This compound plays a critical role in energy metabolism by facilitating ATP production. Additionally, fumaric acid exhibits anti-inflammatory properties by inhibiting the NF-κB signaling pathway via p38 MAPK modulation. Its applications extend to the investigation of conditions such as pregnancy-induced hypertension, making it a valuable tool for metabolic and physiological research. -
Stable Isotope
(R)-STU104-d6 is a deuterium-labeled derivative of (R)-STU104, a potent inhibitor of the TAK1-MKK3 interaction, exhibiting IC50 values of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation, respectively. This compound effectively disrupts the TAK1/MKK3/p38/MnK1/MK2/eIF4E signaling pathways by binding to MKK3, thereby inhibiting its phosphorylation by TAK1. (R)-STU104-d6 is suitable for applications in research focused on ulcerative colitis and related inflammatory conditions. -
Stable Isotope
Budesonide-d6 is a deuterium-labeled derivative of Budesonide, primarily targeting the glucocorticoid receptor. Known for its anti-inflammatory properties, Budesonide-d6 is utilized in research to study mechanisms of action related to asthma and lung diseases. This stable isotope variant allows for enhanced tracking of Budesonide pharmacokinetics and dynamics in biological systems, making it valuable for studies focused on tumor reduction and gene expression modulation.
