Sunitinib-d4 is a deuterated form of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor. It exhibits potent inhibitory activity against VEGFR2 and PDGFRβ, with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d4 effectively impedes the autophosphorylation of Ire1α, thereby blocking RNase activation. This stable isotope is valuable for studies involving drug metabolism and pharmacokinetics, allowing for precise tracking and quantification in biological research.
Sunitinib-d4 is a deuterated form of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor. It exhibits potent inhibitory activity against VEGFR2 and PDGFRβ, with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d4 effectively impedes the autophosphorylation of Ire1α, thereby blocking RNase activation. This stable isotope is valuable for studies involving drug metabolism and pharmacokinetics, allowing for precise tracking and quantification in biological research.
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