Fig. 1 · Structure
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Sunitinib-d4
Stable Isotope
Sunitinib-d4 is a deuterated form of Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor. It exhibits potent inhibitory activity against VEGFR2 and PDGFRβ, with IC50 values of 80 nM and 2 nM, respectively. As an ATP-competitive inhibitor, Sunitinib-d4 effectively impedes the autophosphorylation of Ire1α, thereby blocking RNase activation. This stable isotope is valuable for studies involving drug metabolism and pharmacokinetics, allowing for precise tracking and quantification in biological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1126721-79-6 |
| Applications | Stable Isotope |
| Formula | C22H23D4FN4O2 |
| Molecular Weight | 402.50 |
| SMILES | C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NC(C(N(CC)CC)([2H])[2H])([2H])[2H])=O)=C(C)N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.