VR23-d8 is a deuterated analogue of VR23, designed as a stable isotope for research applications. This small molecule effectively inhibits trypsin-like proteasome activity with an IC50 of 1 nM, chymotrypsin-like proteasomes with an IC50 ranging from 50 to 100 nM, and exhibits an IC50 of 3 μM against caspase-like proteasomes. VR23-d8 is valuable for studies involving proteasomal function and regulation in various biological contexts.
VR23-d8 is a deuterated analogue of VR23, designed as a stable isotope for research applications. This small molecule effectively inhibits trypsin-like proteasome activity with an IC50 of 1 nM, chymotrypsin-like proteasomes with an IC50 ranging from 50 to 100 nM, and exhibits an IC50 of 3 μM against caspase-like proteasomes. VR23-d8 is valuable for studies involving proteasomal function and regulation in various biological contexts.
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