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VR23-d8

Stable Isotope

VR23-d8 is a deuterated analogue of VR23, designed as a stable isotope for research applications. This small molecule effectively inhibits trypsin-like proteasome activity with an IC50 of 1 nM, chymotrypsin-like proteasomes with an IC50 ranging from 50 to 100 nM, and exhibits an IC50 of 3 μM against caspase-like proteasomes. VR23-d8 is valuable for studies involving proteasomal function and regulation in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2733154-83-9
Applications	Stable Isotope
Formula	C₁₉H₈D₈ClN₅O₆S
Molecular Weight	485.93
SMILES	ClC1=CC2=C(C(N3C([2H])(C([2H])(N(C([2H])(C3([2H])[2H])[2H])S(C4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)(=O)=O)[2H])[2H])=CC=N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.