Fig. 1 · Structure
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Tamoxifen-13C6
Stable Isotope
Tamoxifen-13C6 (ICI 47699-13C6) is a stable isotope-labeled variant of the selective estrogen receptor modulator (SERM), Tamoxifen (ICI 47699). This compound effectively blocks estrogen action in breast tissue while activating estrogenic pathways in other tissues such as bone, liver, and uterus. Additionally, it serves as a potent activator of the Hsp90 molecular chaperone, enhancing ATPase activity. Tamoxifen also demonstrates significant inhibitory effects against Ebola virus (EBOV Zaire) and Marburg virus (MARV) with IC50 values of 0.1 μM and 1.8 μM, respectively. Its biological activities include promoting autophagy, inducing apoptosis, and facilitating gene knockout in CreER transgenic mice, making it valuable for various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1346606-38-9 |
| Applications | Stable Isotope |
| Formula | C2013C6H29NO |
| Molecular Weight | 377.47 |
| Synonyms | ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6 |
| SMILES | [H][13C]1=[13CH][13CH]=[13C](/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)[13CH]=[13CH]1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.