Fig. 1 · Structure
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Chloroquine-d5
Stable Isotope
Chloroquine-d5 is a deuterium-labeled analog of Chloroquine, an established antimalarial and anti-inflammatory agent. It functions primarily as an autophagy and toll-like receptor (TLR) inhibitor, making it a valuable tool in various research settings. Notably, Chloroquine-d5 has demonstrated potent in vitro efficacy against SARS-CoV-2 (COVID-19) infection, with an EC50 of 1.13 μM. This stable isotope is particularly useful in tracer studies and pharmacokinetic research involving Chloroquine.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1854126-41-2 |
| Applications | Stable Isotope |
| Formula | C18H21D5ClN3 |
| Molecular Weight | 324.90 |
| SMILES | CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)C([2H])([2H])C([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.