Fig. 1 · Structure
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GW2580-d6
Stable Isotope
GW2580-d6 is a deuterium-labeled variant of GW2580, a selective and orally bioavailable inhibitor of c-Fms kinase. It effectively inhibits human c-Fms kinase in vitro at a concentration of 0.06 μM by acting as a competitive inhibitor of ATP binding, thereby disrupting colony-stimulating factor-1 (CSF-1) signaling pathways. This reagent is valuable for studying signaling processes mediated by c-Fms in various biological contexts and provides insights into macrophage biology and inflammatory responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2733770-48-2 |
| Applications | Stable Isotope |
| Formula | C20H16D6N4O3 |
| Molecular Weight | 372.45 |
| SMILES | NC1=NC(N)=C(CC2=CC(OC([2H])([2H])[2H])=C(OCC3=CC=C(OC([2H])([2H])[2H])C=C3)C=C2)C=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.