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Tivozanib-d6

Stable Isotope

Tivozanib-d6 is a deuterium-labeled form of Tivozanib, a selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), demonstrating IC50 values of 30 nM, 6.5 nM, and 15 nM, respectively. This reagent is employed in chemical research to track the metabolism and pharmacokinetics of Tivozanib in various biological systems. Its application is particularly relevant in studies focused on tumor growth inhibition and angiogenesis modulation, enhancing understanding of targeted cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1714998-87-4
Applications	Stable Isotope
Formula	C₂₂H₁₃D₆ClN₄O₅
Molecular Weight	460.90
Synonyms	AV-951-d6; KRN951-d6
SMILES	O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C34)C=C2Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.