Momelotinib-d4 dihydrochloride hydrate is a deuterium-labeled derivative of Momelotinib, an ATP-competitive inhibitor of Janus kinases JAK1 and JAK2, exhibiting IC50 values of 11 nM and 18 nM, respectively. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for the elucidation of drug metabolism and biodistribution in various biological systems. Additionally, its limited activity against JAK3 makes it a valuable tool for selective JAK inhibition studies.
Momelotinib-d4 dihydrochloride hydrate is a deuterium-labeled derivative of Momelotinib, an ATP-competitive inhibitor of Janus kinases JAK1 and JAK2, exhibiting IC50 values of 11 nM and 18 nM, respectively. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for the elucidation of drug metabolism and biodistribution in various biological systems. Additionally, its limited activity against JAK3 makes it a valuable tool for selective JAK inhibition studies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
