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Atazanavir-d24

Stable Isotope

Atazanavir-d24 is a deuterium-labeled derivative of Atazanavir, which primarily functions as a selective and orally bioavailable HIV-1 protease inhibitor. This compound also exhibits inhibitory effects on CYP3A4 and P-glycoprotein, making it relevant for studies on drug metabolism and transport. Additionally, Atazanavir demonstrates antiviral activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM and has been implicated in the inhibition of cardiac fibrosis and hyperlipidemia, as well as the induction of cell death in malignant glioma. It serves as a valuable research tool for investigating HIV treatment and related pathophysiological mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1092540-58-3
Applications	Stable Isotope
Formula	C₃₈H₂₈D₂₄N₆O₇
Molecular Weight	729.00
Synonyms	BMS-232632-d24
SMILES	[2H]C([2H])([2H])OC(N[C@@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])NC(OC([2H])([2H])[2H])=O)=O)CC2=CC=C(C3=CC=CC=N3)C=C2)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.