Catalog No.
Product Name
Application
Product Information
Citations
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SARS-CoV-2 3CL Protease Inhibitor
Ensitrelvir is a selective, non-covalent, and non-peptidic inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 13 nM. This compound has demonstrated significant antiviral activity against SARS-CoV-2, making it a valuable tool for research into COVID-19 treatments. It is particularly applicable in studies focused on viral replication and therapeutic interventions targeting coronavirus proteases. -
SARS-CoV-2 Inhibitor
Simnotrelvir is a potent inhibitor of SARS-CoV-2 3CLpro, demonstrating an IC50 value of 0.022 µM. This compound exhibits significant antiviral activity against SARS-CoV-2, making it a valuable tool in research focusing on COVID-19 treatment and prevention strategies. Its efficacy in inhibiting viral replication positions it as a critical reagent for investigations into therapeutic options for coronavirus infections. -
SARS-CoV-2 3CL Protease Inhibitor
Ensitrelvir fumarate is a non-covalent, non-peptidic inhibitor targeting the SARS-CoV-2 3CL protease, exhibiting an IC50 of 13 nM. This compound plays a critical role in the inhibition of viral replication by blocking a key enzymatic function essential for SARS-CoV-2 maturation. It is primarily utilized in research applications related to COVID-19 therapeutic development and the exploration of antiviral strategies. -
SARS-CoV-2 Mpro Inhibitor
(±)-Alliin is a compound derived from garlic, recognized for its potential inhibitory effects on the main protease of SARS-CoV-2 (Mpro). This compound demonstrates antiviral activity, making it a candidate for research aimed at understanding and combating SARS-CoV-2 replication and infection mechanisms. Its application in biochemical studies can contribute to the development of therapeutic strategies against COVID-19. -
SARS-CoV-2 Inhibitor
Leritrelvir is an orally active inhibitor of the SARS-CoV-2 main protease, displaying a slow-tight binding mechanism with a Ki value of 8.6 nM. This compound is valuable for research focused on therapeutic strategies against COVID-19, demonstrating potential in the development of antiviral agents aimed at mitigating SARS-CoV-2 replication. Its efficacy as a protease inhibitor makes it a significant candidate for studying protease-related pathways and antiviral drug design. -
SARS-CoV-2 3C-like protease (3CLpro) Inhibitor
Secutrelvir is a potent inhibitor of the SARS-CoV-2 3C-like protease (3CLpro), demonstrating IC50 values of 0.655 nM and 0.697 nM. By forming a reversible covalent bond with the catalytic cysteine C145, Secutrelvir effectively inhibits viral replication, making it a valuable tool in combating SARS-CoV-2. Its efficacy against various SARS-CoV-2 variants supports its potential applications in research focused on coronavirus disease 2019 (COVID-19). -
SARS-CoV-2 Inhibitor
Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 24 nM against wild-type SARS-CoV-2 Mpro. By inhibiting viral polyprotein processing, it effectively disrupts viral replication. Pomotrelvir demonstrates broad antiviral activity against various SARS-CoV-2 variants, including Omicron, and shows an additive effect when co-administered with nucleoside analogs targeting viral RNA synthesis. It is primarily utilized in the research and development of antiviral therapeutics for COVID-19 caused by SARS-CoV-2 and its variants. -
SARS-CoV-2 Inhibitor
Iscartrelvir is a non-covalent inhibitor that targets the 3CLpro protein of SARS-CoV-2. This compound demonstrates potent inhibitory activity against multiple SARS-CoV-2 variants, including Alpha, Beta, Gamma, Delta, Lambda, and Omicron, as well as two other coronaviruses, SARS-CoV and MERS-CoV. Iscartrelvir is valuable for research applications focused on antiviral strategies and the study of coronavirus proteases. -
SARS-CoV-2 Membrane Protein Inhibitor
CIM-834 is an orally bioavailable inhibitor targeting the SARS-CoV-2 membrane protein. It effectively disrupts the assembly of infectious viral particles while preserving viral RNA synthesis. In preclinical studies, CIM-834 has demonstrated a capability to reduce viral titers in lung tissues of SCID mice and prevent the transmission of SARS-CoV-2 among Syrian hamsters. Additionally, it exhibits inhibitory effects on the replication of both SARS-CoV-2 variants and SARS-CoV, making it relevant for COVID-19 research applications. -
SARS-CoV-2 Inhibitor
MPI60 is a potent inhibitor of SARS-CoV-2 main protease (MPro), demonstrating significant antiviral activity and low cellular cytotoxicity. This compound exhibits high metabolic stability in vitro, making it a valuable tool for SARS-CoV-2 research and therapeutic development. Researchers can utilize MPI60 to explore the molecular mechanisms of viral replication and potential intervention strategies. -
SARS-CoV Inhibitor
GS-621763 is an orally bioavailable prodrug of GS-441524 that serves as a potent inhibitor of SARS-CoV-2. It demonstrates significant antiviral activity, effectively reducing viral load to undetectable levels in ferrets infected with SARS-CoV-2. This compound is valuable for research applications related to coronavirus pathogenesis and therapeutic strategies against COVID-19. -
SARS-CoV-2 Inhibitor
Cichoriin is a potent inhibitor of SARS-CoV-2, targeting viral replication and entry into host cells. It demonstrates significant antiviral activity, making it a valuable candidate for research into therapies for severe COVID-19. This compound may facilitate studies on the pathogenesis of the virus and the development of effective treatment strategies. -
SARS-CoV-2 MPro Inhibitor
Mpro inhibitor N3 is a potent inhibitor of the SARS-CoV-2 main protease (MPro), demonstrating an EC50 value of 16.77 µM. This compound exhibits antiviral activity not only against SARS-CoV-2 but also against other coronaviruses, including HCoV-229E, FIPV, IBV, and MHV-A59. Its ability to inhibit viral replication makes it a valuable tool for research in antiviral drug development and coronavirus disease studies. -
SARS-CoV-2 Inhibitor
AT-9010 tetrasodium is a potent inhibitor of the nucleotidyltransferase (NiRAN) domain, crucial for the replication of SARS-CoV-2. This triphosphate active metabolite of AT-527 demonstrates significant antiviral activity by disrupting viral replication processes. Its application is primarily focused on research related to SARS-CoV-2 and the development of therapeutic interventions for COVID-19. -
SARS-CoV-2 PLpro Inhibitor
PF-07957472 is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro). It demonstrates significant antiviral activity, evidenced by an EC50 of 13.9 nM in SARS-CoV-2 infected normal human bronchial epithelial (NHBE) cells. Additionally, PF-07957472 exhibits protective effects in a mouse model adapted for COVID-19, making it a valuable reagent for studying antiviral mechanisms and therapeutic applications related to SARS-CoV-2 infection. -
SARS-CoV Replication Inhibitor
SSAA09E2 is an inhibitor of SARS-CoV replication, specifically targeting the early interactions between the SARS spike protein (S) and its receptor, Angiotensin Converting Enzyme-2 (ACE2). This compound exhibits significant antiviral activity, making it a valuable tool for research into therapeutic strategies against SARS-CoV infections. Its application in studying viral entry mechanisms and potential treatments provides critical insights into coronavirus-related diseases. -
SARS-CoV-2 Inhibitor
SARS-CoV-2-IN-13 is a potent inhibitor of SARS-CoV-2 with a reported IC50 of 0.057 μM. As a niclosamide analogue, it demonstrates enhanced stability in human plasma and liver S9 enzyme assays compared to its predecessor, which may lead to improved bioavailability and longer half-life upon oral administration. This compound is valuable for research applications focused on antiviral therapies and understanding SARS-CoV-2 inhibition mechanisms. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
Anti-HSV Agent
Arabinosylhypoxanthine is a purine nucleoside analog that selectively inhibits viral DNA synthesis. It demonstrates significant anti-herpes simplex virus (HSV) activity, making it a valuable tool for research on herpes simplex virus infections. This compound can be utilized to investigate mechanisms of antiviral action and to develop therapeutic strategies against HSV. -
HBV Inhibitor, EBV Inhibitor
FMAU is a nucleoside analog that primarily inhibits the replication of hepatitis B virus (HBV) and Epstein-Barr virus (EBV). Once phosphorylated by human thymidine kinase, FMAU is incorporated into DNA, serving as a valuable marker for cell proliferation. Its research applications extend to studies on herpes simplex virus infection and various cancer types. -
Griseofulvin Metabolite
6-O-Demethyl griseofulvin is a significant metabolite of Griseofulvin, primarily acting on fungal cell division by inhibiting microtubule formation. This compound demonstrates antifungal activity, making it valuable in studying the efficacy of antifungal treatments and the metabolic pathways involving Griseofulvin. Its applications extend to research focused on dermatophyte infections and fungal resistance mechanisms. -
Metabolite
BTS44596 (Prochloraz-desimidazole-formylamino) is a key metabolite of the antifungal agent Prochloraz, primarily targeting regulatory monitoring applications. This compound serves as a critical target analyte for assessing Prochloraz residue limits in fruits and vegetables. Additionally, it facilitates simultaneous detection using LC-MS/MS methodology, making it an essential tool for food safety and environmental studies. -
Fungicidal Agent
N,N-Bis(3-aminopropyl)dodecylamine serves as a potent fungicidal agent targeting Aspergillus niger. It exerts its antifungal activity by inducing oxidative stress and modulating the activity of various antioxidant and mitochondrial enzymes in a concentration- and time-dependent manner. Additionally, this compound disrupts fungal organelles and alters mitochondrial morphology, leading to impaired mitochondrial functions. N,N-Bis(3-aminopropyl)dodecylamine is valuable for research into fungicidal mechanisms and the role of oxidative stress in Aspergillus niger. -
Antibacterial Agent
Octyl decyldimethyl ammonium chloride is a quaternary ammonium compound functioning as an antibacterial agent. This reagent disrupts microbial cell membranes, resulting in cytotoxic effects. Additionally, it has been observed to increase the secretion of pro-inflammatory cytokine IL-1α, indicating potential immunological implications. Its application may be relevant in studying antibacterial mechanisms and evaluating skin irritation effects in research settings. -
NF-κB Inhibitor, GPx Inhibitor, HIV Replication Inhibitor
α-MSH (11-13) acetate is a selective melanocortin-1 receptor ligand that functions as an inhibitor of NF-κB, GPx activity, and HIV replication. It induces an acute elevation of intracellular calcium levels under certain costimulation or pathway inhibition conditions. This compound effectively suppresses TNF-α-induced NF-κB activation, inhibits colony formation of Staphylococcus aureus and Candida albicans, and demonstrates potential in the study of infections related to these pathogens, as well as in traumatic brain injury, corneal epithelial wounds, and inflammatory bowel disease research. -
Melanin Biosynthesis Inhibitor
Scytalol A is a selective inhibitor of dihydroxynaphthalene melanin biosynthesis in Lachnellula sp. A32-89, effectively disrupting melanin production without affecting the growth of the organism. This compound is valuable for research investigating melanin biosynthesis pathways and can be utilized in studies focused on fungal pigmentation and its applications in various biotechnological fields. -
midazopyridine amide compound
Q203 (IAP6) is a midazopyridine amide compound. Q203 is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. - Clavulanic acid is a mechanism-based β-lactamase inhibitorcombined with penicillin group antibiotics to overcome certain types of antibiotic resistance.
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NNRT inhibitor
MK-1439 is a non-nucleoside reverse transcriptase inhibitor - Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.
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non-ionic emulsifying agent
Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent. -
DprE1 inhibitor
DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect. -
squalene synthetase inhibitor
YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents. - PNU-176798 is an antimicrobial agent, targeting protein synthesis in a wide spectrum of gram-positive and anaerobic bacteria.
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HIV protease inhibitor
Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. -
HIV reverse transcriptase inhibitor
Dapivirine is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) - D-(+)-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans.
- KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
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NNRT inhibitor
Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor, active against wild-type HIV-1 and several nonnucleoside reverse transcriptase inhibitor-resistant strains. -
natural cyclic oligopeptide antibiotic
Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. -
enteroviral capsid binder (CB)
Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). - Ozenoxacin is an experimental quinolone antibiotic being developed for the treatment of impetigo and other dermatological bacterial infections.
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Neuraminidase inhibitor
Laninamivir is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B. - Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
