PF-07957472 is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro). It demonstrates significant antiviral activity, evidenced by an EC50 of 13.9 nM in SARS-CoV-2 infected normal human bronchial epithelial (NHBE) cells. Additionally, PF-07957472 exhibits protective effects in a mouse model adapted for COVID-19, making it a valuable reagent for studying antiviral mechanisms and therapeutic applications related to SARS-CoV-2 infection.
PF-07957472 is an orally active inhibitor of the SARS-CoV-2 papain-like protease (PLpro). It demonstrates significant antiviral activity, evidenced by an EC50 of 13.9 nM in SARS-CoV-2 infected normal human bronchial epithelial (NHBE) cells. Additionally, PF-07957472 exhibits protective effects in a mouse model adapted for COVID-19, making it a valuable reagent for studying antiviral mechanisms and therapeutic applications related to SARS-CoV-2 infection.
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