Catalog No.
Product Name
Application
Product Information
Citations
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Anti-Fungal Agent
Maniwamycin B is an anti-fungal agent that targets fungal cell wall synthesis. It exhibits potent inhibitory activity against a variety of pathogenic fungi, making it valuable for research in fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at understanding fungal biology and developing new antifungal therapies. -
Antibiotic
7-Hydroxytropolone is an antibiotic that exhibits activity against Gram-positive bacteria, Gram-negative bacteria, yeast, and fungi. Its primary mechanism involves the inhibition of 2''-O-Adenylyltransferase, making it a valuable compound for studying bacterial resistance and microbial pathogenesis. This compound is useful in both basic and applied research focusing on antimicrobial agents and their clinical applications. -
Antifungal Compound
(±)-Dunnione is an antifungal compound that operates through the mechanism of redox cycling. This compound exhibits broad-spectrum antifungal activity, making it a valuable tool for studying fungal pathogens. Its application in research encompasses the investigation of antifungal mechanisms and potential therapeutic interventions against various fungal infections. -
Antibacterial Agent
Antifungal agent 85 (compound 24f) functions as a potent antibacterial agent, demonstrating minimum inhibitory concentration (MIC) values ranging from 2.5 to 10 μM against a variety of Gram-positive bacteria. This compound is valuable for research applications focusing on bacterial infections and the development of new antimicrobial therapies. -
Antimicrobial Agent
Darlucin A is an antimicrobial agent that exhibits potent antibacterial and antifungal activity. This compound has shown promising effects against a range of microbial pathogens while demonstrating low cytotoxicity to human cells. Darlucin A is valuable for research applications focused on developing new antimicrobial therapies and exploring mechanisms of resistance in bacteria and fungi. -
Antitumor Antibiotic
Mazethramycin is an antitumor antibiotic that inhibits cellular DNA replication and RNA synthesis, contributing to its antitumor effects. This compound is primarily utilized in cancer research to explore mechanisms of tumorigenesis and evaluate potential therapeutic strategies. Its ability to disrupt fundamental processes in cancer cells makes it a valuable tool for studying antineoplastic therapies. -
Antibiotic
Cyclamidomycin is an acrylamide antibiotic that primarily targets nucleoside diphosphate kinase and pyruvate kinase in Escherichia coli, along with impairing oxidative phosphorylation in rat liver mitochondria. It exhibits broad-spectrum antibacterial activity against various bacteria, including Staphylococcus aureus, Micrococcus flavus, Staphylococcus lutea, Bacillus subtilis, Escherichia coli, Shigella flexneri, Salmonella typhosa, Proteus vulgaris, and Klebsiella pneumoniae, with minimum inhibitory concentrations ranging from 3.12 to 25 mg/ml. This compound is valuable for research on bacterial infections and mitochondrial function. -
Anti-Fungal Agent
Fosfazinomycin B is an anti-fungal agent that exhibits inhibitory activity against plant pathogenic fungi, particularly Xanthomonas oryzae. It demonstrates potential applications in agricultural research for the development of disease-resistant crops. This compound serves as a valuable tool for studies focused on plant-fungal interactions and the exploration of novel antifungal strategies. -
Antimicrobial Agent
Aspergillus niger-IN-1 is a thiazolidine-2,4-dione derivative functioning as an antimicrobial agent. It demonstrates significant antimicrobial activity against a range of bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Salmonella typhi, Candida albicans, and Aspergillus niger, with minimum inhibitory concentration (MIC) values ranging from 5.65 to 11.3 μM/mL. This compound is suitable for research applications in microbiology and therapeutic development targeting resistant infections. -
Anti-Bacterial Agent
Bagremycin B is an antibacterial agent derived from the Streptomyces sp. Tu 4128 strain. It exhibits weak activity against Gram-positive bacteria, as well as the fungi Saccharomyces cerevisiae and Candida albicans. This compound is primarily utilized in research applications focusing on the inhibition of bacterial and fungal growth, contributing to the understanding of antimicrobial mechanisms and the development of new therapeutic agents. -
Fungal Inhibitor
Bromomonilicin is a selective inhibitor of fungal cell membranes. It exerts its antifungal activity by disrupting the integrity of fungal cell membranes, making it a valuable tool for studying plant pathogenic fungal infections, such as those caused by Monilinia fructicola leading to brown rot, as well as superficial mycoses, including dermatophyte infections. This compound is essential for research aimed at understanding and combating fungal diseases in both agricultural and clinical settings. -
Antimicrobial Agent
Gageotetrin B is an antimicrobial agent with significant activity against a range of microorganisms. Demonstrating higher potency towards fungal species, Gageotetrin B exhibits minimum inhibitory concentrations (MIC) ranging from 0.01 to 0.04 μM. This compound is valuable for research in microbiology and antifungal drug development. -
Anti-Fungal Agent
Chandrananimycin A is an anti-fungal agent that demonstrates potent activity against various mucor species. In addition, it exhibits anti-tumor effects against several cancer cell lines, including CCL HT29, MFXF 529L, and MACL McF-7. This compound is valuable in research applications focused on fungal infections and cancer biology. -
Squalene Synthase Inhibitor
E5700 is a potent squalene synthase inhibitor, exhibiting an IC50 of 0.49 nM against squalene synthase from Trypanosoma cruzi epimastigotes. This compound demonstrates notable antiparasitic activity, effectively inhibiting the growth of Trypanosoma cruzi and Leishmania amazonensis. Additionally, E5700 impacts the lipid profile and ultrastructure of multi-drug resistant Candida tropicalis strains, making it a valuable tool for research on parasitic infections and antifungal resistance mechanisms. -
Fungal Inhibitor
Butenafine-d4 is a deuterium-labeled analogue of Butenafine, a potent benzylamine antifungal agent. It exerts its antifungal activity by specifically inhibiting ergosterol biosynthesis at the squalene epoxidation step, which disrupts fungal cell membrane integrity. Butenafine displays effectiveness against a range of dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This reagent is suitable for research applications focused on antifungal mechanisms and the study of fungal pathogens. -
Aminoacyl tRNA Synthetase Inhibitor
Aminoacyl tRNA synthetase-IN-4 is a potent inhibitor of aminoacyl tRNA synthetase, exhibiting an IC50 value of 0.026 μM against Candida albicans prolyl-tRNA synthetase. This compound is valuable for antifungal research, providing insights into the role of aminoacyl tRNA synthetase in fungal biology and potential therapeutic strategies against infections. Its selective inhibition profile makes it an important tool for exploring the mechanisms of antifungal resistance and treatment efficacy. -
Antitumor Antibiotic
Guanine-7-oxide is an antitumor antibiotic that exhibits notable antitumor and antifungal activity, particularly against Candida albicans. This compound has demonstrated the ability to inhibit the replication of various viruses, including herpes virus, infectious hematopoietic necrosis virus (IHNV), and infectious pancreatic necrosis virus (IPNV). Additionally, Guanine-7-oxide shows significant efficacy against mouse L1210 leukemia cells, making it a valuable tool for cancer research and viral studies. -
SDH Inhibitor
SDH-IN-37 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.0263 μM. Additionally, this compound demonstrates significant antifungal activity against pathogens such as Rhizoctonia solani, Sclerotinia sclerotiorum, and Fusarium graminearum, with EC50 values of 0.0144, 0.882, and 1.99 μg/mL, respectively. SDH-IN-37 is therefore a valuable tool for research applications focused on fungal pathogenesis and metabolic regulation in various organisms. -
Antifungal Agent
Bulnesol is a sesquiterpenoid with antifungal properties, isolated from Salvia dorystaechas. It exhibits inhibitory activity against Fusarium moniliforme, with an EC50 value of 0.6 mg/mL. Bulnesol is suitable for research applications focused on fungal infections and the development of antifungal agents. -
Antifungal Agent
3-Piperidinopropiophenone hydrochloride is a mono Mannich base derived from acetophenone, exhibiting significant antifungal activity. This compound functions as an effective antifungal agent, making it valuable for research in mycology and the development of antifungal therapeutics. Its mechanistic pathways and biological implications are of interest for studies aimed at combating fungal infections. -
Histidine kinase Inhibitor
RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies. -
Antimicrobial Agent
Linearmycin B is an antimicrobial agent that exhibits potent antibacterial and antifungal properties. It demonstrates significant inhibitory activity against key pathogens, including Bacillus subtilis, Staphylococcus aureus, Candida albicans, and Saccharomyces cerevisiae, with minimum inhibitory concentrations (MIC) of 0.097, 1.5, 0.0008, and 0.0002 μg/mL, respectively. This compound is valuable for research applications focusing on the development of antimicrobial therapies and the study of microbial resistance mechanisms. -
Fungal Inhibitor
Fenpyrazamine is an antifungal agent that primarily targets 3-keto reductase within the ergosterol biosynthesis pathway. It exhibits significant antifungal, preventative, systemic, and lesion-inhibiting properties, providing a prolonged therapeutic effect. Fenpyrazamine is efficacious against pathogens such as gray mold, stem rot, and brown rot, making it a valuable reagent for research focused on fungal infections and plant pathology. -
Antimicrobial Agent
Damavaricin D functions as an antimicrobial agent, exhibiting potent activity against both Gram-positive and Gram-negative bacteria, as well as antifungal properties. This compound is valuable for research applications focused on the development of new antibacterial and antifungal therapies, especially in the context of emerging resistant strains. Its broad-spectrum efficacy makes it a significant candidate for further investigation in microbiological studies. -
Antibiotic
Melithiazole N is an antibiotic with a primary mechanism of action as a β-methoxyacrylate inhibitor. It exhibits potent antibacterial activity, making it valuable in the study of bacterial resistance and the development of new antimicrobial agents. Melithiazole N is primarily used in research applications focused on understanding bacterial infections and exploring alternatives to traditional antibiotics. -
Opioid Receptor Agonist
Hodgkinsine B acts as an opioid receptor agonist, providing notable analgesic effects and demonstrating anti-injurial properties. Additionally, it functions as an NMDA receptor antagonist and possesses antiviral, antibacterial, and antifungal activities. This compound is valuable for research applications focused on pain management, neuroprotection, and antimicrobial studies. -
Fungal Inhibitor
Inz-4 is a selective inhibitor of mitochondrial cytochrome bc1 in fungi, demonstrating an IC50 of 0.026 μM. This compound effectively disrupts mitochondrial respiration in fungal species, making it a valuable tool for studying fungal metabolism and potential therapeutic applications in antifungal research. Its potent activity underscores its utility in investigating the biochemical pathways of fungi and the development of antifungal agents. -
Fungicide
Pterophyllin 2 is a potent fungicide targeting Rhizopus stolonifer, exhibiting a minimum fungicidal concentration (MFC) of 250 μg/mL. Additionally, Pterophyllin 2 demonstrates significant antifungal activity against Botrytis cinerea and Monilinia fructicola. This compound is valuable in agricultural and microbiological research applications focused on controlling fungal pathogens. -
Antifungal Agent
(Rac)-Luliconazole is a broad-spectrum antifungal agent belonging to the imidazole class of compounds. This racemic isomer exhibits potent antifungal activity, making it effective against a variety of fungal pathogens. It is primarily utilized in research applications focused on dermatological infections and antifungal mechanism investigations. -
Antifungal Agent
Micafungin metabolite M1 is an active metabolite of Micafungin that targets fungal cell wall synthesis, exhibiting potent antifungal activity. This compound is particularly effective against deep fungal infections caused by Candida and Aspergillus species, making it valuable for research applications in mycology and antifungal drug development. Its specific mechanism of action enhances its potential in studies assessing the efficacy of antifungal therapies. -
Fungal Inhibitor
Candicidin A3 is a potent antifungal antibiotic that demonstrates significant inhibitory activity against fungal growth. Its unique three-dimensional structure and seven-membered ring configuration enhance its biological efficacy and interaction with fungal targets. This compound presents potential for development as a therapeutic agent in the treatment of fungal infections, making it a valuable tool for researchers studying antifungal mechanisms and developing new treatments for mycotic diseases. -
14α-lanosterol demethylase Inhibitor
Arasertaconazole is a potent inhibitor of 14α-lanosterol demethylase, an enzyme critical in the biosynthesis of sterols in fungi. This compound exhibits significant antifungal and antibacterial activities, making it valuable in studies focused on the treatment of fungal infections and bacterial pathogens. Its inhibition of key enzymatic pathways underscores its research applications in drug development and microbiology. -
Polyene Antibiotic
Dermostatin A is a polyene antibiotic that exerts potent antifungal activity by disrupting fungal cell membrane integrity. This compound is valuable for research applications focused on investigating fungal infections and evaluating potential therapeutic strategies. Its mechanism of action provides insight into the treatment and pathology of mycoses. -
Fungal
Sartorypyrone A is a monocyclic terpenoid that targets fungal pathways, isolated from the soil fungus Neosartorya fischeri. It demonstrates in vitro growth inhibitory activity against various cancer cell lines, including MCF-7, NCI-H460, and A375-C5. Its potential anticancer properties make it a valuable compound for cancer research and the investigation of fungal biomolecules. -
Anti-Fungal Agent
Neihumicin is an anti-fungal agent effective against Saccharomyces yeast (ATCC 9763) and Penicillium italicum. This compound exhibits resistance to these specific fungal strains, making it a valuable tool for studying fungal biology and developing antifungal therapies. Neihumicin can aid in understanding the mechanisms of fungal resistance and contribute to the research of potential treatments for fungal infections. -
Antifungal Agent
SCH 39304 is an orally active antifungal agent that demonstrates efficacy against systemic candidiasis, aspergillosis, and cryptococcosis, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg in murine models. Pharmacokinetic evaluations reveal a prolonged half-life and significant systemic exposure in both mice and rats. This compound is applicable in anti-infective research, particularly for studying fungal infections and therapeutic interventions. -
Thiazolidinedione Derivative
Antimicrobial agent-41 is a thiazolidinedione derivative with notable antioxidant activity, demonstrated by an IC50 of 27.66 μg/mL. This compound also exhibits significant antidiabetic effects, with an IC50 of 40.01 μg/mL. Furthermore, Antimicrobial agent-41 shows antimicrobial properties against a range of both bacterial and fungal pathogens, making it a valuable tool for research in microbiology and diabetes-related studies. -
Antibiotic
Filipin II is an antibiotic that demonstrates antifungal activity by interacting with membrane sterols, leading to alterations in membrane structure. This compound effectively inhibits the growth of Candida utilis and Saccharomyces cerevisiae, with minimum inhibitory concentrations (MIC) of 0.03 mg/L and 0.2 μg/L, respectively. Filipin II is primarily utilized in research focused on fungal pathogens and membrane biology. -
Antimicrobial Agent
Nemotin is an antimicrobial agent that demonstrates activity against Gram-positive bacteria, mycobacteria, and fungi, while exhibiting weaker effects on Gram-negative bacteria. Its broad-spectrum activity makes it suitable for research applications focused on understanding bacterial and fungal resistance mechanisms. This compound serves as a valuable tool in microbiological studies and the development of new antimicrobial therapies. -
Antibiotic
Demethylblasticidin S is an antifungal antibiotic that primarily targets fungal ribosomes, inhibiting protein synthesis. This compound exhibits significant biological activity against a range of fungal pathogens, making it valuable for studying fungal infections and resistance mechanisms. It is commonly utilized in research applications that involve antifungal drug development and the investigation of ribosomal function. -
Antifungal Antibiotic
Heptaibin is a peptaibol antifungal antibiotic that primarily targets fungal infections. It exhibits significant antimicrobial activity against Gram-positive bacteria, such as Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 8 μg/mL, and demonstrates effectiveness against various fungi including Aspergillus, Candida albicans, and Cryptococcus neoformans, with MIC values ranging from 13 to 32 μg/mL. Additionally, Heptaibin shows moderate activity against Rhabditella pseudoelongata, with an MIC of 50 μg/mL, making it a valuable reagent for research into antifungal treatments. -
Anti-Fungal Agent
Cladosporide B is an anti-fungal agent derived from the strain of Cladosporium sp. IFM 49189. It exhibits potent activity against Aspergillus fumigatus, demonstrating stronger efficacy compared to its analog, Cladosporide A. This compound is valuable for research focused on fungal pathogen inhibition and the development of antifungal therapies. -
Anti-Fungal Agent
Phellinsin is a targeted antifungal agent that selectively inhibits chitin synthase I and II, exhibiting IC50 values of 76 μg/mL and 28 μg/mL, respectively. This compound demonstrates significant antifungal activity against a variety of pathogens, including Colletotrichum lagenarium, Pyricularia oryzae, Aspergillus fumigatus, and Trichophyton mentagrophytes, with minimum inhibitory concentrations (MIC) ranging from 12.5 to 50 μg/mL. Phellinsin serves as a valuable tool for research into fungal biology and the development of antifungal therapies. -
Antibiotic
Polyoxin E is a nucleoside antifungal antibiotic that primarily targets chitin synthesis in fungal cells. It exhibits potent biological activity against various fungal pathogens, making it an effective agent for controlling rice sheath blight. This compound is valuable for research applications focused on plant pathology, mycology, and antifungal drug development. -
Antifungal Isoflavonoid
Phaseollinisoflavan is an antifungal isoflavonoid known for its role as a phytoalexin. It exhibits potent antifungal activity by inhibiting the growth of various fungal pathogens. This compound is particularly useful in research focused on plant defense mechanisms and the development of antifungal agents in agricultural applications. -
Phytoalexin
Phytoalexine is a natural phytoalexin that exhibits antifungal activity by inhibiting spore germination and mycelial growth in fungi such as Phoma lingam and Phoma wasabiae. This compound is of significant interest in the study of plant defense mechanisms and the development of novel pesticides aimed at managing fungal diseases in crops. Its unique biological properties make it a valuable reagent for research applications related to agricultural biotechnology and plant pathology. -
Antifungal
α-Thujene is a natural compound with notable antifungal properties, primarily targeting fungal pathogens. Extracted from eucalyptus trees, it has demonstrated significant efficacy against Macrophomina phaseolina (85% inhibition) and Botrytis cinerea (84% inhibition), outperforming standard antifungal agents like Nystatin. This compound is of particular interest in research applications focused on developing natural antifungal treatments and studying fungal resistance mechanisms. -
Fungal Inhibitor
Stichloroside B1 is a triterpenoid oligosaccharide that acts as a fungal inhibitor. Isolated from the sea cucumber Stichopus chloronotus, it exhibits significant antifungal activity, making it valuable for research in mycology and the development of antifungal agents. Its unique structure and mechanism of action are of particular interest in studying fungal biology and potential therapeutic applications. -
Cytochrome Bc1 Inhibitor
Inz-1 is a selective inhibitor of mitochondrial cytochrome bc1, exhibiting an IC50 of 8.092 μM in yeast and 45.320 μM in human cells. This compound effectively reverses resistance to Fluconazole and other triazole antifungals in Candida albicans, making it a valuable tool for studying antifungal resistance mechanisms and developing new therapeutic strategies. Researchers can utilize Inz-1 to investigate the role of cytochrome bc1 in fungal pathogenesis and drug resistance. -
Antifungal Peptide
LL-25 is an antifungal peptide that exhibits potent candidacidal activity, making it particularly useful in research focused on fungal infections. This compound is a fragment of LL-37, lacking its immunomodulatory effects, which allows for a more targeted investigation of its antifungal properties. LL-25 is applicable in studies exploring therapeutic strategies against fungal pathogens, providing insights into the development of novel antifungal agents.
