Catalog No.
Product Name
Application
Product Information
Citations
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Reverse Transcriptase Inhibitor
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor primarily targeting HIV replication. This compound demonstrates significant anti-HIV activity and has been shown to exhibit anticancer effects in prostate cancer cell lines. Furthermore, Abacavir hydrochloride has the ability to cross the blood-brain barrier and suppress telomerase activity, making it a valuable reagent for research in virology and cancer biology. -
Reverse Transcriptase Inhibitor
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor targeting HIV replication. It demonstrates significant antiviral activity against HIV and exhibits anticancer properties in prostate cancer cell lines. Additionally, Abacavir monosulfate is capable of crossing the blood-brain barrier and effectively suppresses telomerase activity, making it a valuable tool for research in virology and oncology. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
FASN Inhibitor
Cerulenin is a potent natural inhibitor of fatty acid synthase (FASN), derived from the fungus Cephalosporium caeruleus. It acts by inhibiting topoisomerase I catalytic activity, consequently enhancing apoptosis induced by SN-38. Cerulenin exhibits both antifungal and antitumor properties, making it a valuable tool for research in cancer therapies and fungal infections. -
Nonionic Surfactant
Polyethylene glycol mono(4-tert-octylphenyl) ether is a nonionic surfactant that effectively solubilizes lipid membranes, facilitating various laboratory applications. It serves as a crucial excipient in the formulation of vaccines, including split virus influenza vaccines, and is integral during different stages of vaccine manufacturing. In addition to its role in vaccine development, this compound has demonstrated the ability to induce apoptosis in prostate and colon cancer cell lines and to diminish the infectivity of enveloped viruses, such as West Nile Virus (WNV). -
Antibiotic and APN Inhibitor
Actinonin is a naturally occurring antibiotic that functions primarily as an aminopeptidase N inhibitor. It exhibits potent antimicrobial activity and acts as a reversible peptide deformylase (PDF) inhibitor with a Ki value of 0.28 nM. Additionally, Actinonin shows inhibitory effects on matrix metalloproteinases MMP-1, MMP-3, MMP-8, and MMP-9, with respective Ki values of 300 nM, 1,700 nM, 190 nM, and 330 nM. It also possesses pro-apoptotic properties and has demonstrated antiproliferative and antitumor activities, making it a valuable tool for cancer research and therapeutic exploration. -
P2X3 Receptor Antagonist
Aurintricarboxylic acid is a selective allosteric antagonist of the P2X3 receptor, demonstrating nanomolar potency with IC50 values of 72.9 nM for rP2X3R and 8.6 nM for rP2X1R. It exhibits significant anti-influenza activity by inhibiting neuraminidase and serves as a topoisomerase II inhibitor, influencing apoptosis mechanisms. Additionally, aurintricarboxylic acid modulates the TWEAK-Fn14 signaling pathway and acts as a cystathionine-lyase inhibitor with an IC50 of 0.6 μM. Its role in regulating miRNA function is also noteworthy, with an IC50 of 0.47 µM, making it valuable for various biological research applications. -
Antibacterial Agent
Lasalocid is an antibacterial and anticoccidial agent that functions as a feed additive in agricultural applications. It has demonstrated antitumor activity, suggesting potential utility in oncological research. Additionally, Lasalocid is orally bioactive, making it suitable for studies involving gastrointestinal absorption and pharmacokinetics. -
Bacterial Agent And Polyamine Transport System Inhibitor
AMXT-1501 is an antibacterial agent and polyamine transport system inhibitor that targets membrane phospholipids. It exhibits significant antibacterial activity against a range of multidrug-resistant Gram-positive and Gram-negative bacteria, specifically inhibiting capsular biosynthesis in Streptococcus pneumoniae. Additionally, AMXT-1501 interferes with ornithine decarboxylase and polyamine pathways, leading to the inhibition of neuroblastoma cell proliferation. Research applications include studies on multidrug-resistant bacterial infections, pneumococcal infections, and neuroblastoma therapeutics. -
Antifungal Agent
Iturin A is a cyclic lipopeptide that exhibits potent antifungal activity. Iturin A disrupts fungal cell membranes and induces the production of reactive oxygen species (ROS), leading to apoptosis and autophagy in tumor cells. This compound holds promise for research applications in antifungal therapeutics and cancer biology, showcasing notable antitumor effects. -
SCD1 Inhibitor
SSI-4 is a potent stearoyl-CoA desaturase (SCD1) inhibitor with an EC50 of 1.9 nM for mouse SCD1. By blocking the conversion of saturated fatty acids to monounsaturated fatty acids, SSI-4 effectively reduces oleic and palmitoleic acid production. It promotes lipid peroxidation, induces endoplasmic reticulum stress, and activates apoptotic pathways. Additionally, SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. This compound is valuable for studies related to cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections. -
Antibiotic
Bleomycin A5 is a glycopeptide antibiotic that exerts cytotoxic effects primarily through its interaction with Fe2+, leading to the formation of a complex that induces both single-strand and double-strand DNA breaks, while inhibiting DNA replication. Additionally, it targets Drp1-mediated mitochondrial fission and suppresses the PINK1/Parkin pathway-mediated mitophagy, ultimately promoting mitochondria-mediated cellular apoptosis. This compound is valuable in cancer research, particularly in studies focused on mechanisms of apoptosis and DNA damage responses. -
Antibacterial Agent
Lasalocid sodium is an antibacterial and anticoccidial agent primarily utilized in veterinary medicine as a feed additive. This compound exhibits significant antitumor activity, demonstrating potential for additional therapeutic applications. Its oral bioactivity further enhances its utility in various research studies focused on microbial resistance and cancer biology. -
Fungicide Agent
Epoxiconazole is a demethylation inhibitor targeting the Ergosterol biosynthesis pathway. It demonstrates significant inhibitory activity against both carbendazim-resistant and phenamacril-resistant fungal isolates. This compound is widely utilized in agricultural research for the control of various crop diseases, contributing to effective crop management strategies. -
Fungicide
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide that primarily targets the cytochrome bc1 complex, inhibiting mitochondrial respiration through binding at the Qo site. This mechanism disrupts electron transfer, leading to the generation of reactive oxygen species (ROS) and subsequent induction of apoptosis in fungal cells. Azoxystrobin is essential for research applications focusing on fungal physiology, plant pathology, and the development of disease management strategies. -
Fungicide
Fludioxonil is a phenylpyrrole fungicide that targets fungal cell growth by inhibiting the development of plant pathogens such as Sclerotinia sclerotiorum. It exhibits significant biological activity through its ability to disrupt cytoskeletal integrity, induce DNA damage, and promote apoptosis in mouse glioma cells. Additionally, Fludioxonil has been observed to influence tumor growth and metastasis, alongside potential cardiotoxic effects. This compound serves as a valuable tool in agricultural research and studies related to cellular mechanisms of toxicity and cancer progression. -
Antifungal Agent
Isavuconazonium sulfate (BAL8557-002) is an orally active, broad-spectrum antifungal prodrug that is rapidly hydrolyzed in vivo to yield the active triazole compound **Isavuconazole**. It exhibits potent antifungal activity by inhibiting lanosterol 14α-demethylase, a key enzyme in the ergosterol biosynthesis pathway, thereby disrupting fungal cell membrane integrity. Isavuconazonium sulfate is effective against a wide range of pathogenic fungi, including *Aspergillus* and *Mucorales* species, and is used in the study and treatment of invasive aspergillosis, mucormycosis, blastomycosis, and *Acanthamoeba* keratitis. Its excellent oral bioavailability and favorable safety profile make it a valuable therapeutic and research tool in antifungal pharmacology. - Delmopinol is a surface-active cationic compound that functions as an anti-plaque and anti-gingivitis agent. It interacts with the acquired pellicle—a thin salivary film composed of proteins and glycoproteins that coats the teeth and gums—and forms a protective barrier over oral surfaces. This barrier inhibits microbial adhesion and biofilm formation, thereby preventing plaque accumulation and gingival inflammation. Although Delmopinol does not possess direct bactericidal activity, its ability to interfere with bacterial colonization makes it effective in maintaining oral hygiene. It has been approved by the U.S. FDA under the trade name **Decapinol** for the treatment of gingivitis and the prevention of periodontitis.
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actin polymerization inhibitor
Cytochalasin D (also known as Zygosporin A) is a cell-permeable fungal metabolite and a potent inhibitor of actin polymerization. It binds to G-actin, thereby disrupting the G-actin–cofilin interaction and preventing cofilin association with F-actin. Through this mechanism, Cytochalasin D reduces both actin polymerization and depolymerization rates in living cells, leading to profound effects on cytoskeletal organization and cell morphology. In addition, Cytochalasin D suppresses exosome release, consequently decreasing survivin levels within the tumor microenvironment. It also promotes phosphorylation and cytoplasmic retention of YAP, implicating it in the regulation of mechanotransduction and tumor cell signaling. -
Sulfaquinoxaline is a veterinary antimicrobial agent effective against a broad spectrum of Gram-negative and Gram-positive bacteria. It is commonly used for the prevention and treatment of coccidiosis and bacterial infections in livestock and poultry.
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NS3-NS4B interaction inhibitor
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development. -
Hsp90/HSV inhibitor
AT-533 is a potent inhibitor of heat shock protein 90 (Hsp90) and herpes simplex virus (HSV), exhibiting strong antitumor and antiviral activities. It suppresses tumor growth and angiogenesis by disrupting the HIF-1α/VEGF/VEGFR-2 signaling axis, a critical pathway in tumor vascularization and progression. Additionally, AT-533 inhibits key downstream signaling cascades, including Akt/mTOR/p70S6K, ERK1/2, and FAK pathways. In endothelial cells, specifically human umbilical vein endothelial cells (HUVECs), AT-533 effectively inhibits tube formation, cell migration, and invasion, highlighting its anti-angiogenic properties. These combined effects position AT-533 as a promising candidate for cancer therapy and angiogenesis-related disease research. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
glutamine amidotransferase inhibitor
Azaserine (CI-337) is a glutamine analog and competitive inhibitor of glutamine amidotransferase, an enzyme involved in nucleotide biosynthesis. It exhibits both antibiotic and antitumor properties by disrupting glutamine-dependent metabolic processes essential for cell proliferation. Azaserine demonstrates antibacterial activity and has shown antitumor effects in various cancer models. However, it has also been reported to possess tumorigenic potential under certain conditions, warranting cautious evaluation. -
Innate defense regulator
Dusquetide (SGX-942, SGX94) is a synthetic 5-amino acid peptide and innate defense regulator (IDR) with immunomodulatory, anti-inflammatory, anti-infective, and anti-mucositis properties. Upon intravenous administration, it binds to the ZZ domain of sequestosome-1 (p62), activating key signaling pathways such as MAPK p38 and C/EBP involved in innate immune regulation. Dusquetide is a promising agent for modulating immune responses in various inflammatory and infectious conditions. -
Glucosinolate
Sinigrin, a glucosinolate primarily found in cruciferous vegetables, exhibits significant biological activities including anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, along with the inhibition of fat synthesis. This compound is of particular interest in cancer research, as well as studies focused on inflammatory and metabolic diseases. Its diverse therapeutic potential makes it a valuable reagent for exploring various biological pathways. -
Antibacterial Agent
Deoxyshikonin is an antibacterial agent that exhibits significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 17 μg/mL. It enhances the expression of VEGF-C and VEGF-A mRNA in human microvascular endothelial cells, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to specific DNA sequences associated with HIF. Additionally, Deoxyshikonin demonstrates proangiogenic and antitumor effects by inhibiting colorectal cancer via the PI3K/Akt/mTOR signaling pathway, making it valuable for both antibacterial and cancer research applications. -
Influenza Virus Inhibitor
Dehydroandrographolide succinate acts as a potent inhibitor of the influenza virus. Extracted from the medicinal plant Andrographis paniculata, it exhibits immunostimulatory, anti-infective, and anti-inflammatory properties, making it valuable for research into viral pneumonia and upper respiratory tract infections. Additionally, it demonstrates antithrombotic effects by significantly reducing platelet aggregation, as evidenced by a calculated ED50 of 386.9 mg/kg. The compound also mitigates muscle atrophy through the Akt/GSK3β and MuRF-1 signaling pathways. -
Glucosinolate
Sinigrin hydrate is an allyl-glucosinolate known for its diverse biological activities, primarily targeting glucosinolate pathways. This compound exhibits anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, as well as the ability to inhibit fat synthesis. Sinigrin hydrate is valuable for research into tumor biology, inflammatory processes, and metabolic disorders. -
Antibiotic
Chrysomycin A is an antibiotic derived from the Streptomyces genus. It demonstrates significant antitumor properties, alongside effective activity against Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA). In glioblastoma research, Chrysomycin A has been shown to inhibit cancer cell proliferation, migration, and invasion by targeting the Akt/GSK-3β/β-catenin signaling pathway, making it a valuable tool for cancer studies and antibiotic research. -
Furofuran Type Lignan
(+)-Medioresinol is a furofuran-type lignan that exhibits notable antifungal and antibacterial activities. It enhances the efficacy of antibiotics through its antimicrobial and antibiofilm properties and promotes intracellular reactive oxygen species (ROS) accumulation, leading to mitochondrial-mediated apoptosis in Candida albicans. Additionally, (+)-Medioresinol inhibits LPS-stimulated IL-12p40 production and acts as a PGC-1α activator, providing protection against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. This compound is valuable for research into fungal and bacterial infections, inflammatory responses, and ischemic stroke mechanisms. -
GPI/NS2B-NS3/CK1ε Inhibitor
Rhodiolin is a flavonoid that acts as a GPI (glucose 6-phosphate isomerase) and NS2B-NS3 protease inhibitor, with significant implications for cancer and viral research. It demonstrates the ability to inhibit glycolysis in papillary thyroid cancer, leading to suppressed PI3K/AKT/mTOR signaling and induced apoptosis. Additionally, Rhodiolin disrupts dengue viral replication through its action on the NS2B-NS3 protease. With its potential to inhibit CK1ε kinase, it serves as a valuable candidate for developing anticancer strategies and investigating anti-tumor and antiviral mechanisms. -
Fungicide
Triadimefon is an orally active fungicide targeting various fungal species. It has been shown to significantly reduce the phosphorylation of AKT1 and ERK1/2, while increasing levels of phosphorylated AMPK without affecting total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis impacting testosterone synthesis, and affects fetal adrenal development in rodent models. Additionally, it induces metabolic alterations in hepatocytes and impairs spatial learning and memory. -
Bacterial Inhibitor
Vasicine, a quinazoline alkaloid derived from Justicia adhatoda, primarily targets bacterial strains as an inhibitor. This compound is known to activate the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory activities. Its unique biological profile makes Vasicine valuable for research in microbial resistance and inflammation-related studies. -
Bacterial Inhibitor
Vasicine hydrochloride, a quinazoline alkaloid derived from Justicia adhatoda, acts primarily as a bacterial inhibitor. It activates the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory properties. This compound is valuable for research involving antimicrobial activity and cellular signaling pathways, making it a useful tool for studies in infectious disease and inflammation. -
Antibacterial Agent
Canthin-6-one is an indole alkaloid that serves as an effective antibacterial agent. Its primary mechanism involves the inhibition of bacterial growth, making it valuable for research in antimicrobial applications. Additionally, Canthin-6-one exhibits anti-inflammatory properties, suggesting potential in studies related to inflammation. -
Anthocyanin Compound
Cyanidin 3-sambubioside chloride is an anthocyanin compound noted for its ability to inhibit nitric oxide and angiotensin-converting enzyme (ACE) activity. It demonstrates significant antiviral properties, specifically inhibiting influenza neuraminidase with an IC50 of 72 μM and serves as a potent H274Y mutation inhibitor. Additionally, this compound exhibits antioxidant and anti-angiogenic activities, making it suitable for various biological and pharmaceutical research applications. -
Androgen/HSV-1 Inhibitor
Brassicasterol is a metabolite of Ergosterol that primarily targets androgen pathways and exhibits antiviral activity against HSV-1. It demonstrates significant anticancer potential in prostate cancer by dual modulation of AKT and androgen receptor signaling pathways. Additionally, Brassicasterol inhibits sterol δ 24-reductase, contributing to the slowdown of atherosclerosis progression. Furthermore, it serves as a cerebrospinal fluid biomarker for Alzheimer's disease, highlighting its relevance in neurodegenerative research. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
NA Inhibitor
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's. -
HBV Inhibitor
Isoscopoletin, also known as 6-Hydroxy-7-methoxycoumarin, primarily inhibits hepatitis B virus (HBV) replication. It demonstrates significant cytotoxic effects against human CCRF-CEM leukaemia cells and their multidrug-resistant subline, with IC50 values of 4.0 μM and 1.6 μM, respectively. Additionally, Isoscopoletin exhibits anti-inflammatory properties by modulating the MAPK/NF-κB/STAT/AKT signaling pathways, making it a valuable compound for research in virology and cancer biology. -
IL-6 Inhibitor
Koaburaside is an IL-6 inhibitor known for its cytoprotective and anti-inflammatory properties. This natural compound exhibits significant antioxidant activity, with an IC50 value of 9.0 μM in the DPPH free radical scavenging assay. Additionally, Koaburaside effectively reduces histamine release and downregulates the expression of pro-inflammatory cytokines IL-6 and TNF-α in human mast cells. It also demonstrates inhibitory effects on influenza A neuraminidase, highlighting its potential applications in inflammatory and viral research. -
Iron Chelator
Desferricoprogen is a hydrophobic fungal iron chelator that targets iron metabolism. It has been shown to reduce atherosclerotic plaque formation and inhibit lipid peroxidation in the aortic roots of ApoE−/− mice on an atherogenic diet. Additionally, Desferricoprogen effectively lowers levels of oxidized LDL (oxLDL) and inhibits the expression of oxLDL-induced genes such as HO-1, CD36, and TNF-α. Furthermore, it prevents TNF-α-induced endothelial cell activation and maintains endothelial monolayer integrity, making it a valuable tool for research on atherosclerosis. -
Anti-inflammatory Agent
Lucidone is an anti-inflammatory agent derived from the fruit of Lindera erythrocarpa Makino. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 mouse macrophages, while also reducing tumor necrosis factor-alpha (TNF-α) secretion and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Lucidone prevents the translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and inhibits signaling pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK). It also exhibits inhibitory activity against the Dengue virus (DENV), with an EC50 value of 25 μM. -
Antibiotic
Ceftiofur sodium is an antibiotic that acts as a cell wall synthesis inhibitor by targeting bacterial penicillin-binding proteins (PBPs). It exhibits bactericidal activity through the inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis. Additionally, Ceftiofur sodium has anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. This compound is applicable in research related to antibiotic resistance and inflammatory responses. -
EV71 Inhibitor
Mosloflavone is a flavonoid derived from Scutellaria baicalensis Georgi, exhibiting inhibitory activity against Enterovirus 71 (EV71). It targets the VP2 protein, preventing viral replication and inhibiting the synthesis of viral capsid proteins during the early stages of infection. Additionally, Mosloflavone demonstrates biocidal properties by inhibiting Pseudomonas aeruginosa virulence and biofilm formation, making it a valuable tool for research in virology and microbiology. -
Antibacterial Agent
Desfuroylceftiofur is an antibacterial agent and the predominant microbiologically active metabolite of ceftiofur, retaining an intact β-lactam ring. This compound exhibits in vitro activity against a range of Gram-negative and Gram-positive veterinary pathogens, including common equine pathogens. Desfuroylceftiofur is suitable for research applications focused on respiratory infections in veterinary medicine. -
HIV-1 Entry Inhibitor
Trilobatin is a natural sweetener extracted from Lithocarpus polystachyus Rehd, functioning primarily as an HIV-1 entry inhibitor by targeting the HIV-1 Gp41 envelope protein. It demonstrates neuroprotective effects and acts as a selective SGLT1/2 inhibitor, promoting the proliferation of human hepatoblastoma cells. Trilobatin is valuable for research involving HIV-1 entry mechanisms and potential therapeutic applications in hepatoblastoma and neuroprotection studies.
