LinTT1 peptide is a tumor-penetrating peptide that specifically targets the p32 (gC1qR) receptor. This peptide demonstrates enhanced cellular uptake in peritoneal carcinoma (PC) cells, facilitating mitochondrial entry and promoting targeted drug delivery. When conjugated with iron oxide nanoworms, LinTT1 forms a nanocarrier that significantly enhances tumor penetration and targeting in vivo. Additionally, when combined with the pro-apoptotic peptide [D(KLAKLAK)2], LinTT1-functionalized nanocarriers exhibit pronounced tumor suppression in mouse models of peritoneal cancer, highlighting its potential as an effective carrier in cancer research.
LinTT1 peptide is a tumor-penetrating peptide that specifically targets the p32 (gC1qR) receptor. This peptide demonstrates enhanced cellular uptake in peritoneal carcinoma (PC) cells, facilitating mitochondrial entry and promoting targeted drug delivery. When conjugated with iron oxide nanoworms, LinTT1 forms a nanocarrier that significantly enhances tumor penetration and targeting in vivo. Additionally, when combined with the pro-apoptotic peptide [D(KLAKLAK)2], LinTT1-functionalized nanocarriers exhibit pronounced tumor suppression in mouse models of peritoneal cancer, highlighting its potential as an effective carrier in cancer research.
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