Tat-NR2Baa is a control peptide designed to evaluate the specificity of Tat-NR2B9c. This inactive variant features a double-point mutation in the COOH terminal tSXV motif, which prevents binding to the postsynaptic density protein PSD-95. While it retains structural similarity to Tat-NR2B9c, Tat-NR2Baa does not disrupt the PSD-95/NMDAR interaction. It serves as a valuable tool in studies investigating the roles of PSD-95 in NMDAR signaling pathways and related neurophysiological research.
Tat-NR2Baa is a control peptide designed to evaluate the specificity of Tat-NR2B9c. This inactive variant features a double-point mutation in the COOH terminal tSXV motif, which prevents binding to the postsynaptic density protein PSD-95. While it retains structural similarity to Tat-NR2B9c, Tat-NR2Baa does not disrupt the PSD-95/NMDAR interaction. It serves as a valuable tool in studies investigating the roles of PSD-95 in NMDAR signaling pathways and related neurophysiological research.
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