YIGSR-Lys(N3) is an antitumor peptide that targets cellular interactions with laminin I through the inhibition of the 67-kDa laminin-binding protein, effectively hindering the growth and metastasis of leukemic cells. Additionally, it modulates the shear-induced expression of endothelial nitric oxide synthase in laminin cells. This compound serves as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition reactions with alkyne-containing or DBCO/BCN-bearing molecules, respectively. Its versatile reactivity makes it valuable for research in both cancer biology and chemical biology applications.
YIGSR-Lys(N3) is an antitumor peptide that targets cellular interactions with laminin I through the inhibition of the 67-kDa laminin-binding protein, effectively hindering the growth and metastasis of leukemic cells. Additionally, it modulates the shear-induced expression of endothelial nitric oxide synthase in laminin cells. This compound serves as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition reactions with alkyne-containing or DBCO/BCN-bearing molecules, respectively. Its versatile reactivity makes it valuable for research in both cancer biology and chemical biology applications.
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