WT1 126-134 peptide is a peptide derived from the Wilms' tumor oncogene protein (RMFPNAPYL) that targets HLA-A0201. This peptide is known to induce cytotoxic CD8 T cells, which are capable of identifying and eliminating WT1-positive tumor cells. Additionally, WT1 126-134 peptide forms highly stable complexes with H-2Db (mouse) or HLA-A0201 (human), demonstrating a strong affinity (Kd = 0.2 nM) for humanized monoclonal antibodies (IgG1). It is applicable in immunotherapy as a vaccine for T cell activation or as a target for antibody development.
WT1 126-134 peptide is a peptide derived from the Wilms' tumor oncogene protein (RMFPNAPYL) that targets HLA-A0201. This peptide is known to induce cytotoxic CD8 T cells, which are capable of identifying and eliminating WT1-positive tumor cells. Additionally, WT1 126-134 peptide forms highly stable complexes with H-2Db (mouse) or HLA-A0201 (human), demonstrating a strong affinity (Kd = 0.2 nM) for humanized monoclonal antibodies (IgG1). It is applicable in immunotherapy as a vaccine for T cell activation or as a target for antibody development.
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