Tumour-associated MUC1 epitope

Catalog No.: A65691
Bioactive Peptide
Tumour-associated MUC1 epitope is a bioactive peptide targeting the MUC1 mucin, a type I transmembrane glycoprotein characterized by a highly glycosylated extracellular domain composed of repeated 20 amino acid units. This epitope is overexpressed on the surface of various human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma. Its frequent upregulation in cancer cells renders the MUC1 epitope a valuable target for the development of immunotherapeutic strategies, facilitating advancements in cancer treatment research.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTumour-associated MUC1 epitope is a bioactive peptide targeting the MUC1 mucin, a type I transmembrane glycoprotein characterized by a highly glycosylated extracellular domain composed of repeated 20 amino acid units. This epitope is overexpressed on the surface of various human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma. Its frequent upregulation in cancer cells renders the MUC1 epitope a valuable target for the development of immunotherapeutic strategies, facilitating advancements in cancer treatment research.
Product Information
Catalog NumA65691
FormulaC80H127N25O28
Molecular Weight1887.02
CAS Number129437-45-2
SequencePro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser-Thr-Ala-Pro-Pro-Ala-His-Gly-Val-Thr-Ser-Ala
Sequence shorteningPDTRPAPGSTAPPAHGVTSA
SMILESC(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC(CNC(=O)[C@H]2N(C([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@H]4CCCN4)CC(O)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC3)C)=O)CCC2)=O)CO)=O)[C@@H](C)O)=O)C)=O)CCC1)N5[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CO)=O)[C@@H](C)O)=O)[C@@H](C)C)=O)=O)=O)C)=O)CCC5
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