Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Boc-piperidine-oxopiperidin is a linker for PROTAC (Proteolysis Targeting Chimeras) applications, enabling the targeted degradation of proteins through the use of E3 ligase recruitment. This compound plays a crucial role in synthesizing PROTAC LYA914, thereby facilitating studies in targeted protein modulation and degradation mechanisms. Its structural properties make it suitable for various research applications in drug discovery and therapeutic development. -
PROTAC Linker
Amino-PEG4-(CH2)3CO2H is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the degradation of target proteins by enabling the formation of binary complexes between an E3 ligase and the target protein of interest. It is a valuable reagent for researchers developing novel therapeutic strategies that utilize targeted protein degradation. -
PROTAC Linker
m-PEG9-azide serves as a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkynyl compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for chemical biology applications, particularly in targeted protein degradation research. -
PROTAC Linkers
DBCO-PEG2-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing the efficiency of target protein degradation. Its application in PROTAC development makes it a valuable tool for researchers exploring regulated protein degradation pathways in cellular studies. -
PROTAC Linker
Cyclohexane-PEG1-Br is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its cyclohexane moiety provides a flexible and stable connection, facilitating the conjugation of a target protein ligand and an E3 ligase ligand. This compound is instrumental in advancing research on targeted protein degradation, offering potential therapeutic applications in various diseases, including cancers and neurodegenerative disorders. -
PROTAC Linker
Azido-PEG2-C2-sulfonic acid functions as a versatile PEG-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound incorporates an azide moiety, enabling click chemistry applications such as copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its unique properties make it an essential tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
Diethyl 10-bromodecylphosphonate is a phosphonate compound designed for use as a linker in PROTAC (proteolysis-targeting chimeras) synthesis. This alkyl chain-based linker facilitates the recruitment of ubiquitin ligases to target proteins, promoting their degradation via the ubiquitin-proteasome pathway. Its incorporation into PROTACs enables targeted protein degradation, making it valuable in drug discovery and cellular biology research. -
PROTAC Linker
Nonylbenzene-PEG8-OH is a PEG-based linker specifically designed for use in the synthesis of proteolysis targeting chimera (PROTAC) molecules. This compound facilitates the formation of stable and effective PROTACs by connecting the ligand and the E3 ligase components, enhancing target degradation. Its application in chemical research supports the development of targeted therapies and the exploration of protein modulation mechanisms. -
PROTAC Linker
Azido-C1-PEG3-C3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs, functioning through a click chemistry mechanism. This compound features an azide group, enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds bearing DBCO or BCN groups. Its versatility makes it valuable for research applications focused on targeted protein degradation and chemical biology. -
PROTAC Linker
Hydroxy-PEG3-C2-methyl ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound serves as a critical component in facilitating the targeted degradation of proteins, enhancing the overall efficacy of PROTAC-based therapeutic approaches. Its unique structure allows for improved solubility and biocompatibility, making it suitable for various research applications in drug discovery and development. -
PROTAC linker
Azido-PEG2-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. This linker is essential for developing targeted protein degradation strategies and enhances the versatility of bioconjugation in chemical biology research. -
PROTAC Linker
m-PEG4-CH2-aldehyde is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of PROTAC compounds. This compound enhances the solubility and stability of the resulting molecules, making it ideal for targeted degradation studies. It is widely utilized in research applications focused on the development of novel therapeutics through targeted protein degradation. -
PROTAC Linker
Propanol-PEG4-CH2OH is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the formation of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound enhances the solubility and bioavailability of PROTACs while maintaining their functional activity. It is widely utilized in chemical biology research for the development of novel therapeutic agents aimed at specific protein targets. -
PROTAC Linker
Ald-PEG1-C2-Boc is a polyethylene glycol-derived PROTAC linker that enhances the synthesis of bifunctional protein degraders. This compound facilitates the selective targeting and ubiquitination of proteins, enabling the modulation of cellular pathways. Its application is crucial for the development of novel therapeutics in cancer research and other protein homeostasis studies. -
PROTAC Linkers
Methyltetrazine-PEG4-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound incorporates a methyltetrazine moiety, facilitating targeted protein degradation through the recruitment of E3 ligases. Its biologically active structure makes it valuable for research applications in cellular signaling, protein regulation, and the development of innovative therapeutic strategies. -
PROTAC Linker
Propargyl-PEG9-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne moiety, facilitating its role as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG9-OH is essential for creating complex chemical structures in research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
TCO-PEG8-TCO is a PEG-based PROTAC linker designed for the synthesis of protein-targeting chimeras. This linker facilitates the conjugation of E3 ligase recruiters and protein-targeting moieties, enhancing the stability and efficacy of PROTAC compounds. It is instrumental in advancing research in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Bis-PEG13-PFP ester is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the creation of bifunctional molecules that selectively target specific proteins for degradation via the ubiquitin-proteasome system. Its application is essential in the development of novel therapeutic strategies in chemical biology and drug discovery, particularly for modulating protein levels in cells. -
PROTAC Linkers
m-PEG48-amine is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, enabling targeted protein degradation. Its unique structure enhances the solubility and stability of PROTAC constructs, making it a valuable tool in drug discovery and development, particularly for studying protein regulation and therapeutic interventions in various diseases. -
PROTAC Linkers
Methoxy-Tr-NH-PEG7 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It enables the selective degradation of target proteins through the recruitment of E3 ligases, facilitating targeted protein elimination. This linker is crucial for optimizing the pharmacokinetic properties and overall efficacy of PROTAC molecules in therapeutic research applications. -
PROTAC Linker
Bromoacetamido-PEG3-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation, thereby enabling selective modulation of protein levels in various cellular contexts. It is a valuable tool for research applications focused on targeted protein degradation and drug discovery. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of heterobifunctional protein-targeting chimeras. This compound features an azide group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it suitable for advanced applications in chemical biology and targeted protein degradation research. -
PROTAC Linker
Amino-PEG4-hydrazide-Boc is a PEG-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a hydrazide functional group, facilitating the conjugation of large biomolecules to induce targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for a variety of applications in chemical biology and drug discovery. -
PROTAC Linkers
TCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound serves as a versatile building block to facilitate the recruitment of E3 ligases for targeted protein degradation, enabling the modulation of protein levels in biological systems. Its application in the development of PROTACs supports research into therapeutic strategies for various diseases by allowing precise control over protein function and turnover. -
PROTAC Linkers
m-PEG10-NHS ester is a polyethylene glycol (PEG) derivative serving as a versatile PROTAC linker. It facilitates the conjugation of target substrates to E3 ligases, enabling the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for researchers focusing on targeted protein degradation and novel therapeutic strategies in drug discovery. Its hydrophilic nature enhances solubility and biocompatibility in biological systems. -
PROTAC Linkers
Ald-CH2-PEG10-Boc is a PEG-based PROTAC linker that facilitates the construction of PROTAC (PROteolysis TArgeting Chimeras) molecules. This linker enhances the solubility and stability of the conjugates, promoting effective ubiquitination and degradation of target proteins. Ald-CH2-PEG10-Boc is instrumental in chemical biology research for the development of targeted protein degradation strategies, aiding in the investigation of protein function and the treatment of diseases through targeted therapeutic approaches. -
PROTAC Linker
Benzyl-PEG4-MS is a polyethylene glycol (PEG) linker designed for use in proteolysis-targeting chimeras (PROTACs). It facilitates the conjugation of protein degraders, enhancing the efficacy of targeted protein degradation by improving solubility and pharmacokinetic properties. This reagent is essential for researchers focusing on the development of novel therapeutic strategies targeting specific proteins for degradation in various biological contexts. -
PROTAC Linker
Boc-NHCH2-Ph-Py-NH2 is a PROTAC linker designed to facilitate targeted protein degradation through the recruitment of E3 ligases. This compound enhances the stability and efficacy of PROTAC molecules by providing a flexible and efficient connection between the target protein and the ligase. Its utilization in research applications supports the development of innovative therapeutic strategies in the field of targeted protein modulation. -
PROTAC Linkers
2-Bromo-2,2-dimethyl-acetamido-PEG3-acid is a PEG-based linker designed specifically for the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules that can recruit E3 ubiquitin ligases for targeted protein degradation. Its application in research allows for innovative approaches to modulate protein levels and explore the therapeutic potential of targeted protein degradation strategies. -
PROTAC Linker
(2-Aminoethyl)carbamic acid serves as a PROTAC linker within the PEG class, facilitating the development of protein degraders. This compound is instrumental in synthesizing QS-57, enabling targeted protein modulation in various research applications. Its structure supports efficient conjugation for enhanced bioactivity and specificity in cellular studies. -
PROTAC Linker
t-Boc-Aminooxy-PEG11-amine is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by linking an E3 ligase ligand with a protein of interest. Its unique structure enhances solubility and flexibility, making it suitable for various research applications in cellular biology and drug discovery. -
PROTAC Linker
Benzyl-PEG6-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of E3 ligases and target proteins, enhancing the efficiency of targeted protein degradation. Its structural properties support the development of novel therapeutics by allowing precise control over the pharmacological properties of PROTAC molecules. -
PROTAC Linker
Propargyl-PEG4-CH2-methyl ester functions as a PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the assembly of complex molecular architectures. This compound is essential for researchers aiming to develop targeted protein degradation technologies in drug discovery and chemical biology. -
PROTAC Linker
2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) functions as a PEG-based linker for PROTAC (proteolysis-targeting chimera) technology. This compound facilitates the conjugation of biotin to target proteins, enabling the development of targeted protein degradation systems. Its use is essential in synthesizing novel PROTACs for research applications aimed at understanding protein functionality and therapeutic interventions. -
PROTAC linker
N-(PEG1-OH)-N-Boc-PEG2-propargyl is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. This compound features an alkyne group that facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction, enabling efficient conjugation with azide-containing molecules. N-(PEG1-OH)-N-Boc-PEG2-propargyl is ideal for applications in targeted protein degradation studies and the development of novel therapeutic agents. -
PROTAC linker
Methyltetrazine-amido-PEG7-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is suitable for strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linkers
DBCO-PEG2-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-NH-Boc facilitates the construction of complex bioconjugates, making it a valuable tool for targeted protein degradation studies in chemical biology and drug discovery. -
PROTAC Linker
Fmoc-N-amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily through click chemistry. This compound features an azide group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool in chemical biology research and therapeutic development. -
PROTAC linker
Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. This reagent is pivotal for studies in targeted protein degradation, providing a versatile tool for advancing research in cell biology and therapeutic development. -
PROTAC Linker
rel-Biotin-PEG3-C3-NH2 is a PEG-based linker specifically designed for the construction of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by promoting the engagement of E3 ubiquitin ligases. Its biological activity is essential for advancing research in protein homeostasis and therapeutic applications targeting disease-related proteins. -
PROTAC Linker
Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based linker designed for use in the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates efficient conjugation for targeted protein degradation, making it a valuable tool in chemical biology research. It serves as a critical component in the synthesis of bifunctional PROTACs, enabling the selective modulation of protein levels within cells. -
PROTAC Linker
DNP-NH-PEG4-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligase recruitment for targeted protein degradation. Its unique structure allows for enhanced solubility and stability, making it suitable for various biological applications in chemical biology and drug development research. -
PROTAC Linkers
MS-PEG10-THP is a polyethylene glycol (PEG) based linker designed for use in the development of PROTAC (proteolysis-targeting chimera) compounds. This linker promotes efficient conjugation of target proteins to E3 ligases, facilitating targeted protein degradation. It is applicable in various research contexts involving protein modulation and therapeutic development aimed at disease-associated proteins. -
PROTAC Linker
COOEt-bicyclo[2.2.2]octane-CHO is a specialized PROTAC linker that facilitates the conjugation of E3 ligase ligands with SMARCA2 ligands. This compound plays a critical role in developing PROTAC SMARCA2 degrader-6, enabling targeted degradation of SMARCA2 proteins. Its unique structure enhances the efficiency of protein modulation strategies, making it suitable for applications in cancer research and drug discovery focused on proteolysis-targeting chimera technologies. -
PROTAC Linkers
m-PEG37-acid is a polyethylene glycol (PEG)-based linker designed for use in proteolysis targeting chimeras (PROTACs) synthesis. This compound facilitates the construction of PROTACs, enabling targeted protein degradation, which is a valuable strategy in chemical biology and therapeutic development. Its application is crucial for enhancing the solubility and stability of PROTAC constructs, making it an essential reagent in protein engineering and drug discovery research. -
PROTAC Linker
Tos-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target ligands to E3 ligase recruiters, enhancing the effectiveness of targeted protein degradation. Its biochemical properties support various applications in chemical biology and protein modulation research, making it a valuable tool in drug discovery and therapeutic development. -
PROTAC linker
N-(Azido-PEG4)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing substrates. Additionally, it is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) with trans-cyclooctene derivatives, allowing for versatile conjugation strategies in chemical biology studies. -
PROTAC Linker
Propargyl-PEG4-methylamine is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. Its alkyne group enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing partners. This reagent is valuable for researchers investigating targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate serves as a critical linker in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation, making it a valuable tool for studying protein function and regulation. It is notably utilized in the synthesis of PROTAC SMARCA2/4-degrader-27, advancing research in targeted therapies and cellular protein modulation. -
PROTAC Linkers
Ms-PEG3-CH2CH2COOH is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of bifunctional molecules that enhance targeted protein degradation. Its applications include the development of novel therapeutic agents for cancer and other diseases through targeted modulation of protein levels.
