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CRBN ligand-318

Ligand for E3 Ligase

CRBN ligand-318 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound serves as a pivotal component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in cellular systems. Its unique ability to engage with CRBN makes it a valuable tool for investigating ubiquitin-proteasome pathway mechanisms and exploring new therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925079-18-9
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₁N₅O₂
Molecular Weight	257.25
SMILES	O=C1NC(=O)CCN1C=2C=CC(N)=C3N=CN=CC32

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.