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CRBN ligand-624

Ligand for E3 Ligase

CRBN ligand-624 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation makes it a valuable tool in research applications aimed at modulating protein levels within cellular systems.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925099-90-5
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₀N₄O₄
Molecular Weight	274.24
SMILES	O=C(O)C=1C=C(C=C2NN=CC21)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.