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Desamino lenalidomide-7-propyne

Ligand for E3 Ligase

Desamino lenalidomide-7-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to selectively induce target protein degradation makes it valuable in studies of protein regulation and therapeutic development for various diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2412439-23-5
Applications	Ligand for E3 Ligase
Formula	C₁₅H₁₂N₂O₃
Molecular Weight	268.27
SMILES	O=C1NC(=O)C(N2C(=O)C=3C(C#C)=CC=CC3C2)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.