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CRBN ligand-454

Ligand for E3 Ligase

CRBN ligand-454 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. Its unique structure allows for conjugation with a target protein ligand through a linker, enabling the formation of a PROTAC. This compound is vital for studies focused on targeted protein degradation and can significantly contribute to the development of novel therapeutic strategies in cancer and other diseases linked to protein homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925085-21-6
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₄O₃
Molecular Weight	270.25
SMILES	O=CC1=NC=C2C=CC=C(C2=N1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.