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CRBN ligand-548

Ligand for E3 Ligase

CRBN ligand-548 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to form proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application in targeted protein degradation research makes it a valuable tool for studying protein homeostasis and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925102-83-4
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₄O₄
Molecular Weight	286.25
SMILES	O=C(O)C1=CC=2C=NN=CC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.