Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
4-(4-Boc-Piperazino)benzylamine functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the construction of bifunctional molecules that degrade specific disease-related proteins via the ubiquitin-proteasome pathway. It plays a crucial role in targeted protein degradation research and in the design of innovative therapeutic strategies. -
PROTAC Linker
Boc-3,3'-biazetidine hemioxalate is a PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the effective recruitment of E3 ligases, enhancing targeted protein degradation. Its application in drug discovery research allows for the development of innovative therapeutic strategies aimed at modulating protein levels within cells. -
PROTAC Linker
Boc-C17-COOH is a PROTAC (Proteolysis Targeting Chimeras) linker that facilitates the synthesis of PROTACs, enabling targeted protein degradation. Its chemical structure supports the effective conjugation of target proteins and E3 ligases, making it a valuable tool for research in protein homeostasis and regulation. This linker plays a crucial role in advancing studies on targeted therapeutics and the development of innovative treatments for various diseases. -
PROTAC Linker
Methyl 8-bromooctanoate serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs) that can selectively degrade target proteins. This compound plays a crucial role in expanding the toolbox for targeted protein degradation research and therapeutic applications. Its unique structure enhances the potency and specificity of PROTACs in various biological assays. -
PROTAC Linker
3-(4-Bromobenzoyl)propionic acid serves as a PROTAC linker, facilitating the synthesis of targeted protein degradation compounds. This reagent is essential for creating bifunctional molecules that promote the ubiquitination and subsequent degradation of specific proteins, enabling studies on protein function and regulation. Researchers can utilize this compound in drug discovery and development processes focusing on targeted therapy. -
PROTAC Linker
Methyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate is a PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound enables selective degradation of target proteins through targeted ubiquitination, playing a crucial role in modulating cellular pathways. Its application in PROTAC synthesis allows researchers to explore innovative therapeutic strategies in cancer and various diseases by harnessing the power of targeted protein degradation. -
PROTAC Linker
4-(2-((tert-Butoxycarbonyl)amino)ethyl)benzoic acid functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the development of targeted protein degradation strategies, which have significant implications in cancer research and other fields of therapeutic discovery. Researchers utilize this linker to enhance the specificity and efficacy of PROTACs in modulating protein levels within cellular systems. -
PROTAC Linker
Benzyl (4-hydroxybutyl)carbamate serves as a PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent linkage of target proteins to E3 ligases, promoting targeted protein degradation. It is essential for advancing research in targeted therapies and unraveling protein function in cellular processes. -
PROTAC Linker
Cbz-PEG2-prop-1-yne is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By connecting target proteins to E3 ligases, this compound enhances targeted protein degradation, making it a valuable tool in the study of protein function and regulation. Its application in drug discovery and development enables researchers to explore novel therapeutic strategies for various diseases. -
PROTAC Linker
Methyl 5-bromo-4-oxopentanoate is a chemical linker designed for use in the development of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, facilitating the targeted degradation of proteins by recruiting an E3 ligase. It is essential for researchers investigating targeted protein degradation and exploring therapeutic avenues in cancer and other diseases. -
PROTAC Linkers
Thiol-PEG6-alcohol is a poly(ethylene glycol)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a thiol group that facilitates conjugation and linkage with targeted proteins, enhancing the delivery and degradation of specific intracellular proteins. It is a valuable reagent for researchers developing novel PROTACs for targeted protein degradation in therapeutic applications. -
PROTAC Linker
Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate is a key linker utilized in the design and synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. It facilitates targeted protein degradation by connecting ligand and E3 ligase components in PROTACs. This compound is essential for advancing research in targeted therapies and studying protein interactions and degradation pathways. -
PROTAC Linker
tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by linking them to E3 ligases, thereby allowing for targeted therapeutic applications. Its utility in PROTAC synthesis supports research in various fields, including cancer biology and drug discovery. -
PROTAC Linker
tert-Butyl N-[3-(hydroxymethyl)cyclobutyl]carbamate serves as a PROTAC linker, facilitating the effective synthesis of proteolysis targeting chimeras (PROTACs). Its unique structural characteristics improve the conjugation efficiency and stability of the resultant PROTACs. This compound is essential for researchers investigating targeted protein degradation and exploring new therapeutic strategies in various disease models. -
Ligands for E3 Ligase
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand targeting E3 ubiquitin ligase, an essential component of the ubiquitin-proteasome pathway. This compound is designed for use in research applications involving protein degradation and modulation of cellular processes. It can be conjugated to other ligands via a linker to create more complex structures, such as 22-SLF, facilitating the study of E3 ligase interactions and functions. -
Ligands for E3 Ligase
CRBN ligand-83 is a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology. This compound enhances the recruitment of E3 ligases to specific substrates, enabling efficient ubiquitination and subsequent proteasomal degradation of target proteins. CRBN ligand-83 is a valuable tool in chemical biology research for studying protein function and the development of therapeutics that harness the ubiquitin-proteasome system. -
CRBN Ligand
NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip) is a ligand that targets Cereblon (CRBN), a key component of the E3 ubiquitin ligase complex. This compound facilitates the synthesis of PROTAC BRD4 Degrader-22, enabling targeted degradation of the BRD4 protein. Its applications include research in the field of protein degradation and regulation of gene expression, providing a valuable tool for studying the role of BRD4 in various biological processes. -
Thalidomide Analogue
Tetrafluoro-thalidomide is a fluorinated analogue of thalidomide, targeting E3 ligases to activate ubiquitination of proteins for subsequent proteolysis. This compound shows potential significance in studying protein degradation pathways and the therapeutic implications of inhibiting or enhancing E3 ligase activity. Its unique fluorinated structure allows for further derivatization, facilitating the exploration of novel compounds in chemical biology and drug development applications. -
Ligand for E3 Ligase
CRBN ligand-282 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras) to promote targeted protein degradation. Its utility in drug discovery and development makes it a vital tool for studying protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-486 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a key component in the development of proteolysis-targeting chimeras (PROTACs) by facilitating the recruitment of CRBN to target proteins. This reagent is instrumental in cellular studies aimed at understanding protein degradation pathways and has potential applications in targeted protein modulation for therapeutic purposes. -
Ligand for E3 Ligase
CRBN ligand-611 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It is designed to be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studies focused on targeted protein degradation and E3 ligase-mediated pathways in cellular biology. -
Ligand for E3 Ligase
CRBN ligand-656 is an E3 ubiquitin ligase ligand that specifically recruits the cereblon (CRBN) protein. It serves as a critical component in the development of PROTACs by linking to target protein ligands through a spacer or linker. This functionality enables selective degradation of target proteins, facilitating research in protein regulation and therapeutic interventions in diverse biological systems. -
Ligand for E3 Ligase
CRBN ligand-688 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand via a suitable linker. CRBN ligand-688 is valuable for research applications focused on targeted protein degradation and the exploration of synthetic biology pathways. -
Ligand for E3 Ligase
CRBN ligand-492 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the development of proteolysis-targeting chimeras (PROTACs) when conjugated with a target protein ligand through a linker. CRBN ligand-492 is valuable for researchers exploring targeted protein degradation and the modulation of protein homeostasis in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-742 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-742 is utilized in research focused on targeted protein degradation, offering the potential to develop novel therapeutic strategies through the modulation of protein homeostasis. -
E3 Ubiquitin Ligase Ligand
E3 Ligase Ligand 59 is a selective ligand for E3 ubiquitin ligases, particularly FDU73. This compound facilitates the development of PROTACs (proteolysis targeting chimeras) that harness the ubiquitin-proteasome pathway for targeted protein degradation. Its unique properties make it a valuable tool for studying protein regulation and cellular pathways in chemical biology research. -
Ligand for E3 Ligase
CRBN ligand-252 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is integral for the development of PROTACs (proteolysis-targeting chimeras), allowing for targeted protein degradation in therapeutic applications. CRBN ligand-252 is a valuable tool for researchers investigating ubiquitin-mediated proteolysis and its implications in various biological processes and disease states. -
Ligand for E3 Ligase
CRBN ligand-268 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-268 is valuable for research applications in targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-409 is a small molecule that targets the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to specific target proteins, enabling the targeted degradation of those proteins through the PROTAC technology platform. This compound is valuable for researchers investigating protein regulation, degradation pathways, and therapeutic applications in diseases involving dysregulated protein levels. -
Ligand for E3 Ligase
CRBN ligand-546 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), which enables the targeted degradation of specific proteins. It is valuable for research in targeted protein degradation and cellular regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-199 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC). It is invaluable for studies involving targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-678 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation for innovative therapeutic strategies. Its ability to connect to target protein ligands through a linker positions CRBN ligand-678 as a valuable tool in chemical biology and drug discovery research. -
Ligand for E3 Ligase
CRBN ligand-496 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be strategically linked to target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it valuable for research applications in drug discovery and functional genomics. -
Ligand for E3 Ligase
CRBN ligand-460 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when conjugated with a target protein ligand via a suitable linker. This compound is a valuable tool for research in protein modulation and therapeutic strategies involving targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions. -
Ligand for E3 Ligase
CRBN Ligand-312 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs by linking it to other target protein ligands via a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for investigating cellular pathways and protein regulation. -
Ligand for E3 Ligase
CRBN ligand-594 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera). It is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways mediated by CRBN. -
Ligand for E3 Ligase
CRBN ligand-338 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. By utilizing a linker, CRBN ligand-338 can be employed to create PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of intracellular proteins. This compound serves as a valuable tool for research applications in protein homeostasis, targeted protein degradation, and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-632 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-632 serves as a valuable tool for researchers investigating ubiquitin-proteasome pathway mechanisms and developing novel therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-724 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to synthesize a PROTAC (Proteolysis Targeting Chimera), enabling the selective degradation of specific proteins in cellular assays. Its utility in drug discovery and cellular biology research highlights its relevance in the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-310 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is valuable for research applications involving ubiquitin-proteasome pathway manipulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-315 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of cereblon protein. This compound can be conjugated to a target protein ligand via a linker to create a PROTAC (Proteolysis Targeting Chimera). Its utility in targeted protein degradation makes it a valuable tool for studying protein function and developing potential therapeutics in the field of cellular biology. -
Ligand for E3 Ligase
CRBN ligand-319 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), enabling selective degradation of specific proteins. It serves as a valuable tool in the study of targeted protein degradation and has potential applications in drug discovery and therapeutic development. -
Thalidomide Analog
Thalidomide-O-amido-C8-NHBoc is a thalidomide analog featuring an amide linkage, an octyl alkyl chain, and a carbamate protecting group. This compound serves as a valuable tool in the exploration of thalidomide's mechanisms of action and its derivatives' biological activity. It is applicable in research related to anti-inflammatory and immunomodulatory effects, aiding in the development of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-227 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimera) technology. This compound is instrumental in research applications focused on elucidating protein turnover and modulating cellular pathways linked to disease. -
Ligands for E3 Ligase
E3 ligase Ligand 65 is a specific ligand for E3 ubiquitin ligases, facilitating targeted protein degradation through the ubiquitin-proteasome pathway. It serves as a crucial intermediate in the synthesis of AZ'3137, which is utilized in various research applications, including studies on protein homeostasis and therapeutic development. This compound aids in advancing the understanding of E3 ligase function and its implications in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-679 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits CRBN, facilitating targeted protein degradation through the formation of Proteolysis Targeting Chimeras (PROTACs) when linked to a target protein ligand. This compound is valuable in research applications involving protein regulation and therapeutic strategies aimed at disease modulation through selective proteasomal degradation. -
Ligand for E3 Ligase
CRBN ligand-387 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool in research applications focused on targeted protein degradation and E3 ligase-mediated pathways. -
Ligand for E3 Ligase
CRBN ligand-743 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of cereblon to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its key biological activity lies in promoting targeted degradation of specific proteins, making it valuable for research in protein regulation and therapeutic applications. -
Ligand for E3 Ligase
5-Fluoro-pomalidomide is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. This compound effectively recruits the cereblon protein, making it a valuable tool for the design of PROTACs (Proteolysis Targeting Chimeras) when linked to target protein ligands through a suitable linker. Research applications include studies in targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity.
