BTK-IN-39

Catalog No.: A81340
Ligands for Target Protein for PROTAC
BTK-IN-39 is a ligand targeting Bruton’s tyrosine kinase (BTK), designed for the synthesis of PROTAC BTK Degrader-11. This compound enables the selective degradation of BTK, facilitating studies on its biological functions and role in disease models, particularly in hematological malignancies. Its application in PROTAC technology allows for innovative approaches to therapeutic intervention by modulating protein levels within cells.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBTK-IN-39 is a ligand targeting Bruton’s tyrosine kinase (BTK), designed for the synthesis of PROTAC BTK Degrader-11. This compound enables the selective degradation of BTK, facilitating studies on its biological functions and role in disease models, particularly in hematological malignancies. Its application in PROTAC technology allows for innovative approaches to therapeutic intervention by modulating protein levels within cells.
Product Information
Catalog NumA81340
FormulaC36H43N9O4
Molecular Weight665.78
CAS Number2736510-62-4
SMILESCC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)C(OC(C)(C)C)=O)C=C5)=C4)=NC=N3)=C1
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