Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for Target Protein for PROTAC
SMARCA2 ligand-6 is a selective ligand for the SMARCA2 protein, functioning within the context of proteolysis-targeting chimera (PROTAC) technology. This compound facilitates the targeted degradation of SMARCA2, enabling researchers to study its biological functions and roles in various cellular processes. It is a valuable tool for investigating therapeutic strategies in cancer and other diseases linked to dysregulation of chromatin remodeling factors. -
Ligands for Target Protein for PROTAC
LC3B ligand 1 is a specific ligand for the target protein utilized in PROTAC technology. It plays a crucial role in synthesizing PROTAC CDK9 autophagic degrader 1, facilitating targeted protein degradation through autophagy. This compound is valuable in studies aimed at investigating protein turnover, cellular homeostasis, and the potential therapeutic applications of PROTACs in cancer and other diseases. -
SMARCA2 Ligand
SMARCA2 ligand-8 acts as a selective ligand for the target protein SMARCA2, facilitating the synthesis of the PROTAC SMARCA2/4-degrader-35. This compound is instrumental in research applications focused on targeted protein degradation, offering insights into the modulation of gene regulation and chromatin remodeling. Its utility in developing innovative degraders highlights its significance in the study of cancer biology and potential therapeutic interventions. -
Ligands for Target Protein for PROTAC
AKT ligand-2 is a selective ligand targeting the AKT protein. It can be utilized in the synthesis of PROTACs, specifically by linking with VHL ligand (S,R,S)-AHPC, to create compounds like PROTAC MS21. This reagent is instrumental in cellular research focused on targeted protein degradation and the modulation of AKT signaling pathways. -
Ligands for Target Protein for PROTACs
TRIB2 ligand-1 is a specific ligand for the TRIB2 protein, facilitating the development of PROTACs designed for targeted protein degradation. This compound plays a crucial role in the synthesis of PROTAC TRIB2 degrader-1, which can be employed in research focused on protein regulation and degradation pathways. Its application in such studies supports investigations into various cellular mechanisms and potential therapeutic targets. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-2 is a selective ligand designed for the targeted degradation of SMARCA2 and SMARCA4 proteins via the PROTAC (proteolysis-targeting chimeras) approach. This compound facilitates the ubiquitination and subsequent proteasomal degradation of these essential chromatin remodeling proteins, making it a valuable tool in studies focused on cancer biology and epigenetic regulation. Researchers can utilize SMARCA2/4-ligand-2 to investigate the role of SMARCA2/4 in various cellular processes and to explore therapeutic strategies for diseases linked to their dysregulation. -
CRBN Modulator
ZXH-1-161 is a selective modulator of cereblon (CRBN) that induces the degradation of GSPT1 in a CRBN-dependent manner. This compound effectively inhibits the proliferation of multiple myeloma cells and demonstrates significant antitumor activity. Its unique mechanism of action makes it a valuable tool for investigating CRBN-targeted therapies in cancer research. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
PROTAC Linkers
5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies. -
PROTAC Linker
DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise bioconjugation. Its application is critical in the development of targeted protein degradation strategies, enhancing the ability to study protein interactions and manipulate cellular processes. -
PROTAC Linker
Biotin-PEG3-azide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies. Biotin-PEG3-azide is essential for advancing research in molecular biology and therapeutic development involving PROTAC technology. -
PROTAC Linkers
L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications. -
PROTAC Linker
4-Bromobutanoic acid tert-butyl ester functions as a PROTAC linker, facilitating the synthesis of PROTACs for targeted protein degradation. This compound plays a critical role in modulating protein levels within cells, enabling the study of protein function and potential therapeutic developments. Its incorporation into PROTACs aids in the design of innovative approaches for drug discovery and development in cancer and other diseases. -
PROTAC Linker
N-Boc-4,4'-bipiperidine is a versatile PROTAC linker that facilitates the design and synthesis of targeted protein degraders. This compound enables the construction of PROTACs such as BRD9 Degrader-5, which are crucial for modulating protein levels through the ubiquitin-proteasome system. Its role in the development of molecular probes for selective degradation highlights its significance in chemical biology and therapeutic research applications. -
PROTAC Linker
2-Chloroethanamine hydrochloride is a PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ligases, facilitating targeted protein degradation. It is widely employed in chemical biology for the development of innovative therapeutics that leverage the ubiquitin-proteasome system. -
PROTAC Linker
3-Mercaptopropionic acid NHS ester functions as a linker in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating the conjugation of target proteins for degradation. This reagent enables the synthesis of innovative PROTACs by providing a reactive moiety for efficient attachment to both the ubiquitin ligase and the target protein. Its unique structure supports targeted proteolysis and enhances the specificity and efficacy of therapeutic interventions in protein homeostasis research. -
PROTAC Linker
Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatile chemical reactivity makes it suitable for developing targeted protein degradation strategies in chemical biology research and drug discovery applications. -
PROTAC Linkers
Ac4GalNAz is an alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Ac4GalNAz serves as an essential tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG3-aldehyde is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances solubility and facilitates the development of bifunctional molecules that can simultaneously engage a target protein and an E3 ligase. Its application is crucial for advancing research in targeted protein degradation strategies and drug discovery. -
PROTAC Linkers
EGNHS is an alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins in cellular systems. EGNHS is valuable for research applications focused on targeted protein degradation and the development of novel therapeutic strategies in various disease contexts. -
PROTAC Linkers
Biotin-PEG4-NHS ester is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific proteins within cells. Its unique structure promotes solubility and improves the stability of PROTACs, making it a valuable tool for drug discovery and development in molecular biology and therapeutic research. -
PROTAC Linker
Amino-PEG3-C2-Azido is a PEG-based linker designed for use in PROTAC applications, facilitating the synthesis of targeted protein degraders, such as the PARP1 degrader iRucaparib-TP3. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and drug discovery research. -
PROTAC Linker
L-Homopropargylglycine is an alkyne-containing amino acid analog of methionine designed for use as a PROTAC linker. This compound facilitates the synthesis of PROTACs by enabling robust click chemistry reactions with azide-functionalized partners, such as Alexa Fluor. Its unique structure allows for precise manipulation of target protein degradation pathways, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
Biotin alkyne is a PEG-based linker designed for the synthesis of PROTACs, targeting the ubiquitin-proteasome system. As a click chemistry reagent, it features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. This functionality facilitates the efficient assembly of bifunctional degraders, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Biotin-PEG4-azide is a biotin-labeled PEG-based linker designed for constructing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Biotin-PEG4-azide can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds, facilitating advanced applications in targeted protein degradation research. -
PROTAC Linker
Biotin-PEG4-alkyne is a biotin-functionalized linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This PEG-based compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient conjugation with azide-containing molecules. Its application is vital in developing PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
Azido-PEG4-NHS-ester is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry mechanisms. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition reactions with DBCO or BCN groups. Its unique properties make it a valuable tool for researchers focused on the development of targeted protein degradation strategies. -
PROTAC Linkers
N-Boc-piperazine is a versatile alkyl/ether-based linker utilized in the synthesis of PROTACs, specifically for the development of PD-1/PD-L1 degrader-1. Its unique structure facilitates the formation of bifunctional molecules, enabling targeted protein degradation. This compound is essential for research applications focused on enhancing cancer immunotherapy and understanding the mechanisms of targeted protein modulation. -
PROTAC Linker
2-Boc-2,6-Diazaspiro[3.3]heptane is a versatile PROTAC linker facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the development of targeted protein degradation strategies, enabling the selective modulation of protein levels within biological systems. Its structural attributes make it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linkers
Alkynyl myristic acid is a PROTAC linker characterized by its alkyl chain structure. It serves as a versatile click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This compound is essential for the synthesis of PROTACs, facilitating targeted protein degradation studies in various biological research applications. -
PROTAC Linker
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the conjugation of target proteins for targeted protein degradation applications. This compound possesses a maleimide functional group, allowing for site-specific linking to thiol-containing biomolecules. It is essential for the synthesis of PROTACs aimed at modulating protein levels within cells, making it a valuable tool in drug discovery and development research. -
PROTAC Linker
TCO-PEG4-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs. Its primary mechanism involves click chemistry, specifically the inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG4-NHS ester facilitates targeted protein degradation, making it a valuable tool for research applications in pharmacology and molecular biology, particularly in the development of novel therapeutics. -
PROTAC Linker
Sulfo-NHS-Acetate is a PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs) through the formation of stable amide bonds. This compound features an alkyl chain that facilitates the conjugation of various target proteins, enhancing the efficacy of targeted protein degradation. It serves as an essential building block for researchers aiming to develop innovative therapeutics in targeted protein modulation and degradation studies. -
PROTAC Linker
Methyltetrazine-Ph-NHS ester is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a tetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) moieties. Its key biological activity lies in enabling targeted protein degradation, providing a valuable tool for researchers exploring protein function and dynamics in cellular systems. Methyltetrazine-Ph-NHS ester is suitable for applications in chemical biology and drug discovery research. -
PROTAC Linker
Azido-PEG2-C2-acid is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. Its versatile reactivity makes it suitable for various applications in chemical biology and drug development. -
PROTAC Linker
Azido-PEG1 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Azido-PEG1 is essential for advancing research in targeted protein degradation and bioconjugation applications. -
PROTAC Linkers
Azido-PEG5-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) applications, facilitating the synthesis of novel degrader molecules. This compound features an azide functional group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, as well as in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Azido-PEG5-amine is essential for researchers exploring targeted protein degradation and enhancing drug discovery efforts. -
PROTAC Linker
Boc-NH-PEG2-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ubiquitin ligases to target proteins, enhancing selective degradation pathways. Its unique structure promotes solubility and biocompatibility, making it suitable for various research applications in drug discovery and therapeutic development focused on targeted protein degradation. -
PROTAC Linker
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide functions as a PEG-based PROTAC linker, facilitating the synthesis of targeted protein degraders. This compound is a versatile click chemistry reagent featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Azido-PEG4-alcohol is a PEG-based PROTAC linker designed for the synthesis of PROTAC molecules. This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug discovery applications. -
PROTAC Linkers
Aeide-C1-NHS ester is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) compounds. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique reactivity profiles make it an ideal candidate for developing innovative tools in targeted protein degradation research. -
PROTAC Linker
DBCO-Biotin is a PROTAC linker featuring an alkyl chain structure that facilitates the synthesis of PROTACs. As a click chemistry reagent, it contains a DBCO moiety that efficiently undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes DBCO-Biotin a valuable tool in targeted protein degradation research, allowing for the precise construction of bifunctional compounds necessary for therapeutic development. -
PROTAC Linker
Azido-PEG1-amine serves as a versatile linker for PROTAC (Proteolysis Targeting Chimera) synthesis, facilitating the targeted degradation of proteins. This PEG-based compound features an azide group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it well-suited for various chemical biology applications, including the development of novel therapeutics. -
PROTAC Linkers
Biotin-PEG2-C2-iodoacetamide is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by promoting the recruitment of E3 ligases to specific proteins of interest. It is particularly useful in studying protein regulation and function in various biological contexts, advancing research in targeted therapeutics and drug discovery. -
PROTAC Linkers
Biotin-PEG4-amine is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances target protein degradation by facilitating the recruitment of E3 ligases via biotin-streptavidin interactions. Its application in PROTAC development supports research in targeted protein degradation for therapeutic interventions. -
PROTAC Linkers
Azido-PEG3-NHS ester is a PEG-based PROTAC linker featuring an azide functional group, which facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it ideal for targeted protein degradation studies and related applications in chemical biology. -
PROTAC Linker
Boc-NH-C4-Br is an alkyl chain-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by promoting the recruitment of E3 ligases to specific proteins of interest. Boc-NH-C4-Br is ideal for research applications focused on developing innovative therapeutic strategies in drug discovery and cellular biology. -
PROTAC Linker
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances target specificity and cellular degradation efficiency by linking E3 ligases to target proteins. Its application in PROTAC development enables the study of targeted protein degradation mechanisms, providing valuable insights in drug discovery and therapeutic interventions. -
PROTAC Linker
DBCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-containing molecules, enabling precise conjugation. This reagent is essential for researchers developing PROTACs aimed at targeted protein degradation, thereby enhancing insights in various biological processes and therapeutic applications. -
PROTAC Linker
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research.
