BMS-1166-N-piperidine-COOH is a ligand designed to target E3 ligase for PROTAC applications. This compound serves as a key component in the synthesis of PD-1/PD-L1 degrader-1, which facilitates the degradation of the PD-1/PD-L1 complex, a crucial immune checkpoint. With a potent PD-1/PD-L1 interaction inhibition demonstrated by an IC50 of 1.4 nM, BMS-1166-N-piperidine-COOH effectively reverses the suppressive effects of the PD-1/PD-L1 pathway on T cell activation, making it valuable for cancer immunotherapy research.
BMS-1166-N-piperidine-COOH is a ligand designed to target E3 ligase for PROTAC applications. This compound serves as a key component in the synthesis of PD-1/PD-L1 degrader-1, which facilitates the degradation of the PD-1/PD-L1 complex, a crucial immune checkpoint. With a potent PD-1/PD-L1 interaction inhibition demonstrated by an IC50 of 1.4 nM, BMS-1166-N-piperidine-COOH effectively reverses the suppressive effects of the PD-1/PD-L1 pathway on T cell activation, making it valuable for cancer immunotherapy research.
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