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CRBN ligand-896

E3 Ligase Ligand of PROTAC

CRBN ligand-896 is an E3 ligase ligand utilized in the development of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent facilitates targeted protein degradation by enabling the selective ubiquitination of the epigenetic coactivator p300. It serves as a valuable tool in the investigation of protein regulation and therapeutic strategies in cancer and other diseases associated with dysregulated epigenetic modifiers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2504234-93-7
Applications	E3 Ligase Ligand of PROTAC
Formula	C₁₆H₁₁BrN₂O₃
Molecular Weight	359.17
SMILES	O=C(C(N1C(C2=CC=CC3=C(Br)C=CC1=C23)=O)CC4)NC4=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.