Fig. 1 · Structure
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DNP-PEG4-NHS ester
PROTAC Linkers
DNP-PEG4-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound facilitates the conjugation of ligands to E3 ligases, enhancing the efficiency and selectivity of PROTAC molecules. Its utility in drug discovery and research applications includes the development of novel therapeutic strategies aimed at degrading specific proteins in cellular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 858126-78-0 |
| Applications | PROTAC Linkers |
| Formula | C21H28N4O12 |
| Molecular Weight | 528.47 |
| SMILES | O=C(CC1)N(OC(CCOCCOCCOCCOCCNC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)=O)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.