Fig. 1 · Structure
Documents & Downloads
Mal-amido-PEG8-NHS ester
PROTAC Linker
Mal-amido-PEG8-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of E3 ligase recruiters with target proteins, enhancing the selective degradation of disease-causing proteins. Its application is particularly valuable in drug discovery and development, allowing for the investigation of targeted protein modulation in various biological pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 756525-93-6 |
| Applications | PROTAC Linker |
| Formula | C30H47N3O15 |
| Molecular Weight | 689.71 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.