Fig. 1 · Structure
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7-Octynoic acid
PROTAC Linkers
7-Octynoic acid serves as a versatile linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound bridges two distinct ligands—one targeting an E3 ubiquitin ligase and the other directed towards the target protein, facilitating the selective degradation of undesired proteins through the ubiquitin-proteasome system. Additionally, 7-Octynoic acid features an alkyne group, making it suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, further expanding its utility in chemical biology and medicinal chemistry applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 10297-09-3 |
| Applications | PROTAC Linkers |
| Formula | C8H12O2 |
| Molecular Weight | 140.18 |
| SMILES | C#CCCCCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.