5-HT Receptors

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  1. Agonist (12)
  2. Antagonist (26)
  3. Inhibitor (1)
  4. Modulator (2)


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Catalog No. Product Name Application Product Information
A10017

5-hydroxytryptophan (5-HTP)

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5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
A10048

Agomelatine

5-HT Receptor antagonist
Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist.
A11799

Almotriptan malate (Axert)

5-HT Receptor agonist
Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
A11310

Alosetron

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Alosetron is a 5-HT3 antagonist that an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract.
A14989

Alosetron Hydrochloride

5HT3-receptor antagonist
Alosetron is s Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
A11801

Aripiprazole (Abilify)

5-HT1A receptor agonist
Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
A10091

Asenapine maleate

H1 antagonist
Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.
A11208

BMY 7378

5-HT1A agonist
BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
A11178

BRL-15572

5-HT1D receptor antagonist

BRL-15572 is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

A10231

Clomipramine HCl

5-HT Receptor agonist
Clomipramine is a blocker of the following transporters:Serotonin transporter (SERT) (Ki = 0.14 nM),Norepinephrine transporter (NET) (Ki = 54 nM),Dopamine transporter (DAT) (Ki = 3,020 nM),Glycine transporter (GlyT/LeuT).
A10287

Dapoxetine hydrochloride

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Dapoxetine works by inhibiting serotonin transporter, increasing serotonins action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.
A11705

Duloxetine

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Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It is effective for major depressive disorder and generalized anxiety disorder (GAD).
A11717

Duloxetine HCl

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Duloxetine Hydrochloride is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of stress urinary incontinence, as well as depression.
A13075

Eletriptan

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Eletriptan is a selective 5-hydroxytryptamine 1B/1D (5-HT1B) receptor agonist
A11418

Eletriptan hydrobromide

5-HT1B/1D receptor agonist
Eletriptan hydrobromide is a selective SR-1B/SR-1D agonist.
A15096

Granisetron

5-HT3 antagonist
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
A10437

Granisetron Hydrochloride

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Granisetron HCl is a serotonin 5-HT3 receptor antagonist
A15838

GSK163090

5-HT1A/B/D receptor antagonist
GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively.
A10497

Ketanserin (Vulketan Gel)

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Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
A13664

Ketanserin tartrate

5HT2A antagonist
Ketanserin tartrate is a salt of Ketanserin. Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors.
A15501

Lerisetron

5HT3 receptor antagonist
Lerisetron is a serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity.
A12378

Lorcaserin

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Lorcaserin is a Novel Selective Human 5-Hydroxytryptamine2C Agonist
A12598

lorcaserin hydrochloride (APD-356)

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lorcaserin hydrochloride (APD-356) is a serotonin 2C receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults
A12521

Lu AE58054

5-HT6R antagonist
Lu AE58054 is a potent and selective 5-HT6 receptor antagonist.
A15148

LY 344864

5HT1F agonist
LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

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