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WAY-100635

Name: WAY-100635
Brand: Adooq Bioscience
SKU: A11182
Availability: InStock
Rating: 5 (1 reviews)

Cat. No. A11182 CAS 162760-96-5

5HT1A antagonist

WAY-100635 was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D4 receptor.

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Biological Activity

Target & Activity

Target	Activity	Value
sPLA2	pIC50	8.87
sPLA2	pA2	9.71

Cellular Effect

Cell Line	Activity	Value	Description	Reference
CHO	EC50	7.1 nM	Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells	[PMID: 15239661]
HEK293-EBNA	IC50	0.91 nM	Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation counting	[PMID: 21520940]
JAR	IC50	> 4500 nM	Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cells	[PMID: 15239661]

Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	162760-96-5
Applications	5HT1A antagonist
Formula	C₂₅H₃₄N₄O₂
Molecular Weight	422.56
SMILES	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	74 mg/mL (137.38 mM)
Water	Insoluble
Ethanol	74 mg/mL (137.38 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 9 mg/mL
Vehicle: 2% DMSO+40% PEG 300+2% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

Qi Liu, .et al. , Environ Sci Technol, 2024, Apr 30;58(17):7577-7587 PMID: 38630542