PF-04995274
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg. |
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Catalog Num | A22497 |
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Formula | C23H32N2O6 |
Molecular Weight | 432.52 |
CAS Number | 1331782-27-4 |
SMILES | OC1(CN2CCC(COC3=NOC4=C3C(O[C@H]5COCC5)=CC=C4)CC2)CCOCC1 |
Synonyms | PF-04995274, PF 04995274, PF04995274, PF-4995274, PF 4995274, PF4995274. |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2