CXC chemokine receptors (CXCR)



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Catalog No. Product Name Application Product Information
A11315

AMD 070

CXCR4 antagonist
AMD 070 is a CXCR4 chemokine receptor antagonist.
A11953

AMD 3465 Hexahydrobromide

CXCR4 antagonist
AMD 3465 is a potent, selective CXCR4 antagonist.
A14997

AMD-070 HCl

CXCR4 antagonist
AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
A13074

AMD3100 (Plerixafor)

CXCR Inhibitor
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
A15941

AZD-5069

CXCR2 antagonist
AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD.
A11104

INCB 3284 dimesylate

HCCR2 antagonist
INCB 3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity.
A11136

INCB8761 (PF-4136309)

CCR2 Antagonist
INCB8761(PF-4136309) is a potent, selective, and orally bioavailable CCR2 antagonist.
A10556

Maraviroc (UK-427857)

CCR antagonist
Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
A11127

MK-0812

CCR2 antagonist
MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.
A12596

MSX-122

CXCR4 Inhibitor
MSX-122 is an orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration.
A15924

NSC5844

CCR1 agonist
NSC5844 is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties.
A10913

Plerixafor 8HCl (DB06809)

CXCR antagonist
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
A12383

Reparixin

CXCR Inhibitor
Reparixin is an inhibitor of CXCR2 function, which attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.
A15227

RS 504393

CCR2 antagonist.
RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 uM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).
A14195

SB265610

CXCR2 antagonist
N/A
A15234

SCH 563705

CXCR2/CXCR1 antagonist
SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist.
A11555

SCH-527123 (Navarixin)

CXCR1 and CXCR2 receptors antagonist
SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.
A11097

SRT3109

-
SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
A11577

SRT3190

SIRT1 activator
SRT3190 is a potent CXCR2 ligand.
A10971

Vicriviroc Malate

CCR5 antagonist
Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52).
A15276

Vicriviroc maleate

CCR5 antagonist
Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
A12588

WZ811

CXCR antagonist
WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist.

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