AMG 487

Catalog No.: A21162

CXCR3 antagonist

AMG 487

AMG 487 Chemical Structure

CAS NO. 473719-41-4

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$130.00
10 mg
$223.00
50 mg
$662.00
100 mg
$1,325.00
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Biological Activity

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
In vitro DMSO 97 mg/mL (160.7 mM)
Water Insoluble
Ethanol 97 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.57 mL 82.84 mL 165.68 mL
0.5 mM 3.31 mL 16.57 mL 33.14 mL
1 mM 1.66 mL 8.28 mL 16.57 mL
5 mM 0.33 mL 1.66 mL 3.31 mL

*The above data is based on the productmolecular weight 603.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21162
Actions Antagonist
CAS No. 473719-41-4
Formula C32H28F3N5O4
M. Wt 603.59
Purity >98%
Synonyms AMG-487, AMG487
SMILES O=C(N([[email protected]@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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