AMG 487

Catalog No.: A21162
CXCR3 antagonist
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
Grouped product items
Product Name Price Stock Qty
AMG 487 5mg
$130.00
In stock
AMG 487 10mg
$223.00
In stock
AMG 487 50mg
$662.00
In stock
AMG 487 100mg
$1,325.00
In stock
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Biological Activity
Discription AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
Targets
Target Value
Product Information
Catalog Num A21162
Formula C32H28F3N5O4
Molecular Weight 603.59
CAS Number 473719-41-4
SMILES O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
Synonyms AMG-487, AMG487
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 97 mg/mL (160.7 mM)
Water Insoluble
Ethanol 97 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.57 mL 82.84 mL 165.68 mL
0.5 mM 3.31 mL 16.57 mL 33.14 mL
1 mM 1.66 mL 8.28 mL 16.57 mL
5 mM 0.33 mL 1.66 mL 3.31 mL
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