MDM2

Inhibitory Selectivity
Catalog No.Inhibitor Name Mdm2Other
A10657Nutlin-3
**
A11501Nutlin-3a
***
A11502Nutlin-3b
*
A16348MX69
**
A15440MI-773 (SAR405838)
****
p53
A14211Idasanutlin (RG-7388)
****
A11523RG-7112
***
A14118YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



18 Item(s)

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Catalog No. Product Name Application Product Information
A11179

NSC-207895 (XI-006)

MDMX Inhibitor

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

A15202

p53 and MDM2 proteins-interaction-inhibitor racemic

p53-MDM2 interaction inhibitor
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
A15201

p53 and MDM2 proteins-interaction-inhibitor chiral

p53-MDM2 interaction inhibitor
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
A15440

MI-773

MDM2 inhibitor
MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
A14394

AMG232

MDM2 inhibitor
AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
A14118

YH239-EE

Mdm2 inhibitor
YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.
A14211

Idasanutlin (RG7388)

MDM2/p53 Inhibitor
Idasanutlin is a potent and selective p53-MDM2 inhibitor.
A11502

Nutlin 3b

MDM2 inhibitor
Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
A11501 SALE

Nutlin 3a

MDM2 inhibitor
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
A15352

SJ 172550

MDMX inhibitor
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
A11523

RG7112

selective p53-MDM2 inhibitor
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
A14423

MI-773 (SAR405838)

Mdm2 inhibitor
MI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affinity (Ki=0.88 nM) and blocks the p53-MDM2 interaction.
A16326

NVP-CGM097

MDM2 inhibitor
NVP-CGM097 is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
A13797

Kevetrin HCl

-
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
A14051

WK23

MDM2/MDMX inhibitor
WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX, its median inhibitory concentration (IC50) values to MDM2/MDMX are 1.17 and 36 uM, respectively
A13582

MDM2 Inhibitor

MDM2 inhibitor
MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex.
A10657 SALE

Nutlin-3

Mdm2 antagonist
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
A16348

MX-69

MDM2/XIAP inhibitor
MX-69 is the MDM2/XIAP inhibitor, used for cancer treatment.

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