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MDM2

Catalog No.	Product Name	Application	Product Information
A14394	AMG232	MDM2 inhibitor	AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). Mdm2 p53
A14211	Idasanutlin (RG7388)	MDM2/p53 Inhibitor	Idasanutlin is a potent and selective p53-MDM2 inhibitor. Mdm2 p53
A12547	Lithocholic acid	MDM4 Inhibitor	Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. FXR PXR vitamin D receptor
A13582	MDM2 Inhibitor	-	MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex. Mdm2 p53
A14423	MI-773	Mdm2 inhibitor	MI-773 is an orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity.
A15440	MI-773	MDM2 inhibitor	MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM. Mdm2 p53
A11179	NSC-207895 (XI-006)	MDMX Inhibitor	NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. p53 MdmX
A11501	Nutlin 3a	MDM2 inhibitor	Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Mdm2 p53
A11502	Nutlin 3b	MDM2 inhibitor	Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. Mdm2 p53
A10657	Nutlin-3 Product Citations (2) AG Evstafieva ,etc. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4. Cell death & disease, 2014, 5(11), e1511. AA Garaeva ,etc. Mitochondrial dysfunction induces SESN 2 gene expression through Activating Transcription Factor 4. , 2016, 15(1), 64-71.	Mdm2 antagonist	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis. Mdm2
A15201	p53 and MDM2 proteins-interaction-inhibitor chiral	-	p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Mdm2 p53
A15202	p53 and MDM2 proteins-interaction-inhibitor racemic	-	p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Mdm2 p53
A11523	RG7112	selective p53-MDM2 inhibitor	RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
A15352	SJ 172550	MDMX inhibitor	SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. MdmX
A14118	YH239-EE	Mdm2 inhibitor	YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer. Mdm2 p53