MDM2

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  1. Antagonist (1)
  2. Inhibitor (9)


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Catalog No. Product Name Application Product Information
A14394

AMG232

MDM2 inhibitor
AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
A14211

Idasanutlin (RG7388)

MDM2/p53 Inhibitor
Idasanutlin is a potent and selective p53-MDM2 inhibitor.
A12547

Lithocholic acid

MDM4 Inhibitor
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption.
A13582

MDM2 Inhibitor

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MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex.
A14423

MI-773

Mdm2 inhibitor
MI-773 is an orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity.
A15440

MI-773

MDM2 inhibitor
MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
A11179

NSC-207895 (XI-006)

MDMX Inhibitor

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

A11501

Nutlin 3a

MDM2 inhibitor
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
A11502

Nutlin 3b

MDM2 inhibitor
Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
A10657

Nutlin-3

Mdm2 antagonist
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
A15201

p53 and MDM2 proteins-interaction-inhibitor chiral

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p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
A15202

p53 and MDM2 proteins-interaction-inhibitor racemic

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p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
A11523

RG7112

selective p53-MDM2 inhibitor
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
A15352

SJ 172550

MDMX inhibitor
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
A14118

YH239-EE

Mdm2 inhibitor
YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.

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