HDM201

Catalog No.: A16834

MDM2 inhibitor

HDM201

HDM201 Chemical Structure

CAS NO. 1448867-41-1

HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.

Availability: In stock

Package Price Qty
2 mg
$75.00
5 mg
$135.00
10 mg
$200.00
50 mg
$585.00
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Biological Activity

HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.
In vitro DMSO 98 mg/mL (176.44 mM)
Water Insoluble
Ethanol 3 mg/mL (5.4 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90.02 mL 180.05 mL
0.5 mM 3.6 mL 18 mL 36.01 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16834
Actions Inhibitor
CAS No. 1448867-41-1
Formula C26H24Cl2N6O4
M. Wt 555.41
Purity >98%
Synonyms NVP-HDM201, HDM 201, HDM-201
SMILES O=C1N(C2=CC(Cl)=CN(C)C2=O)[[email protected]@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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