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Biological Activity
HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.
| In vitro | DMSO | 98 mg/mL (176.44 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (5.4 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18 mL | 90.02 mL | 180.05 mL |
| 0.5 mM | 3.6 mL | 18 mL | 36.01 mL |
| 1 mM | 1.8 mL | 9 mL | 18 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
*The above data is based on the productmolecular weight 555.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16834 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1448867-41-1 |
| Formula | C26H24Cl2N6O4 |
| M. Wt | 555.41 |
| Purity | >98% |
| Synonyms | NVP-HDM201, HDM 201, HDM-201 |
| SMILES | O=C1N(C2=CC(Cl)=CN(C)C2=O)[C@@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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