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Publications citing Adooq Products
Nutlin-3 Citations (4)
- Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749每1763 PMID: 29743291
- Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
- Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64每71 PMID: 26771712
- A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
Chemical Information
| Catalog Num | A10657 |
|---|---|
| Actions | Antagonist |
| M. Wt | 581.5 |
| Formula | C30H30Cl2N4O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 548472-68-0 |
| Synonyms | Nutlin3 |
| SMILES code | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| Chemical Name | 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one |
Description |
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis. | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 85.98 mL | 171.97mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
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