Nutlin-3

Name: Nutlin-3
Brand: Adooq Bioscience
SKU: A10657
Rating: 100 (4 reviews)

Catalog No.: A10657

Mdm2 antagonist

Product Citations (4)

Nutlin-3 Chemical Structure

CAS NO. 548472-68-0

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Availability: In stock

Package	Price	Qty
5 mg	$65.00
25 mg	$200.00
50 mg	$360.00
100 mg	$560.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Nutlin-3

Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376

Biological Activity

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Solubility *

In vitro	DMSO	87 mg/mL (149.61 mM)
	Water	Insoluble
	Ethanol	26 mg/mL (44.71 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.2 mL	85.98 mL	171.97 mL
0.5 mM	3.44 mL	17.2 mL	34.39 mL
1 mM	1.72 mL	8.6 mL	17.2 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 581.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10657
Actions	Antagonist
CAS No.	548472-68-0
Formula	C30H30Cl2N4O4
M. Wt	581.5
Purity	>98%
Synonyms	Nutlin3
SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.