Nutlin-3

Catalog No.: A10657

Mdm2 antagonist

Nutlin-3

Nutlin-3 Chemical Structure

CAS NO. 548472-68-0

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Availability: In stock

Package Price Qty
5 mg
$65.00
25 mg
$200.00
50 mg
$360.00
100 mg
$560.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
  • Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
  • Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
  • A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376

Biological Activity

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.98 mL 171.97 mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10657
Actions Antagonist
M. Wt 581.5
Formula C30H30Cl2N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 548472-68-0
Synonyms Nutlin3
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

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