NSC-207895 (XI-006)

Name: NSC-207895 (XI-006)
Brand: Adooq Bioscience
SKU: A11179
Rating: 100 (268 reviews)

Catalog No.: A11179

MDMX Inhibitor

NSC-207895 (XI-006) Chemical Structure

CAS NO. 58131-57-0

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$700.00
100 mg	$1,200.00
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Biological Activity

Targets

p53	MDMX
N/A	2.5 μM

Solubility *

In vitro	DMSO	0.39 mg/mL (1.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.81 mL	179.05 mL	358.1 mL
0.5 mM	7.16 mL	35.81 mL	71.62 mL
1 mM	3.58 mL	17.91 mL	35.81 mL
5 mM	0.72 mL	3.58 mL	7.16 mL

*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11179
Actions	Inhibitor
CAS No.	58131-57-0
Formula	C11H13N5O4
M. Wt	279.25
Purity	>98%
Synonyms	NSC207895
SMILES	CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.