NSC-207895 (XI-006)

Catalog No.: A11179

MDMX Inhibitor

NSC-207895 (XI-006) Chemical Structure

CAS NO. 58131-57-0

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$700.00
100 mg
$1,200.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Targets
p53 MDMX
N/A2.5 μM
In vitro DMSO 0.4 mg/mL (1.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.05 mL 358.1 mL
0.5 mM 7.16 mL 35.81 mL 71.62 mL
1 mM 3.58 mL 17.91 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL

*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11179
Actions Inhibitor
M. Wt 279.25
Formula C11H13N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 58131-57-0
Synonyms NSC207895
SMILES CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]

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