RO8994

Catalog No.: A20865

MDM2 inhibitor

RO8994

RO8994 Chemical Structure

CAS NO. 1309684-94-3

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

Availability: In stock

Package Price Qty
5 mg
$81.00
10 mg
$140.00
50 mg
$414.00
100 mg
$828.00
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Biological Activity

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.3 mL 81.5 mL 163 mL
0.5 mM 3.26 mL 16.3 mL 32.6 mL
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 613.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20865
Actions Inhibitor
M. Wt 613.51
Formula C31H31Cl2FN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1309684-94-3
Synonyms RO 8994, RO-8994
SMILES O=C([[email protected]](N[[email protected]]1CC(C)(C)C)[[email protected]](C2=CC=CC(Cl)=C2F)[[email protected]@]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC

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