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Caspase
Catalog No. | Inhibitor Name | Pan-Caspase | Caspase-1 | Caspase-2 | Caspase-3 | Caspase-4 | Caspase-5 | Caspase-6 | Caspase-7 | Caspase-8 | Caspase-9 | Caspase-10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
A10984 | VX-765 (Belnacasan) | ** | *** | |||||||||
A12373 | Z-VAD-FMK | * | ||||||||||
A13503 | Z-DEVD-FMK | |||||||||||
A14915 | Q-VD-OPh hydrate | **** | **** | *** | *** | |||||||
A14919 | Caspase-3/7 Inhibitor I | **** | *** | |||||||||
A12611 | Z-VEID-FMK | |||||||||||
A12637 | Z-VDVAD-FMK | |||||||||||
A12697 | Z-DQMD-FMK | |||||||||||
A12800 | Z-IETD-FMK | |||||||||||
A14358 | Z-LEHD-FMK | |||||||||||
A14284 | Z-FA-FMK | |||||||||||
A15300 | Ivachtin | **** | ||||||||||
A15392 | Boc-D-FMK | |||||||||||
A14916 | Z-WEHD-FMK | |||||||||||
A15816 | Ac-DEVD-CHO | *** | * | **** | ** | ** | ** | *** | **** | ** |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
Catalog No. | Product Name | Application | Product Information |
---|---|---|---|
A15291 |
Ac-LEHD-AFC
|
Fluorogenic caspase substrate |
Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
|
A15319 |
Ac-IEPD-AFC
|
Fluorogenic caspase substrate |
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
|
A15308 |
PETCM
|
Caspase-3 activator |
PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
|
A15300 |
Ivachtin
|
Caspase-3 inhibitor |
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
|
A15294 |
AZ 10417808
|
Caspase-3 inhibitor |
AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
|
A12611 |
Z-VEID-FMK |
Caspase-6 inhibitor |
Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2.
|
A14919 |
Caspase-3/7 Inhibitor I |
Caspase-3/7 Inhibitor |
Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
|
A14916 |
Z-WEHD-FMK |
Caspase inhibitor |
Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
|
A14915 SALE |
Q-VD-OPh hydrate |
Caspase inhibitor |
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
|
A12637 |
Z-VDVAD-FMK |
Caspase-2 inhibitor |
Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
|
A14358 |
Z-LEHD-FMK |
Caspase-9 Inhibitor |
Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
|
A12697 |
Z-DQMD-FMK |
Caspase-3 inhibitor |
Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
|
A13503 SALE |
Z-DEVD-FMK |
Caspase-3 Inhibitor |
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
|
A14100 |
Nivocasan (GS-9450) |
Caspase inhibitor |
Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
|
A12800 |
Z-IETD-FMK |
caspase 8 inhibitor |
Z-IETD-FMK is a specific inhibitor of caspase 8.
|
A12373 SALE |
Z-VAD-FMK |
Pan Caspase Inhibitor |
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
|
A15816 |
Ac-DEVD-CHO |
Caspase Inhibitor |
Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.
|
A16317 |
Z-YVAD-FMK |
Caspase-1 inhibitor |
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
|
A16340 |
Z-VAD(OH)-FMK |
Caspase inhibitor |
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
|
A15392 |
Boc-D-FMK
|
Caspase inhibitor |
BOC-D-FMK is a Novel inhibitor of Caspase-3.
|
A10984 SALE |
VX-765 (Belnacasan) |
Caspase-1/4 inhibitor |
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
|
A13704 |
25-hydroxy Cholesterol |
- |
25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types
|
A14284 |
Z-FA-FMK |
Irreversible Cysteine Protease inhibitor |
Z-FA-FMK is an irreversible cysteine protease inhibitor.
|
A13070 SALE |
LY573636 (Tasisulam) |
Apoptosis inducer |
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
|
A11944 |
Apoptosis Activator 2 |
Apoptosis Activator |
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
|
A11090 SALE |
PAC-1 |
Caspase activator |
PAC-1 is first procaspase activating compound.
|
A16381 |
Z-FA-FMK |
Cysteine protease inhibitor |
Z-FA-FMK is an irreversible inhibitor of cysteine protease
|