Fig. 1 · Structure
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Rosuvastatin-d6 sodium
Stable Isotope
Rosuvastatin-d6 sodium is a deuterated form of Rosuvastatin sodium, a competitive inhibitor of HMG-CoA reductase (HMGCR) with an IC50 of 11 nM. This reagent not only inhibits cholesterol synthesis but also significantly reduces low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. In addition, Rosuvastatin-d6 sodium affects hERG current conductance and diminishes the interaction between heat shock protein 70 (Hsp70) and hERG protein, making it valuable for studies focused on lipid metabolism and cardiac ion channel function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2070009-41-3 |
| Applications | Stable Isotope |
| Formula | C22H21D6FN3NaO6S |
| Molecular Weight | 509.56 |
| SMILES | O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C([2H])([2H])[2H])C([2H])([2H])[2H])N=C(N(C)S(C)(=O)=O)N=C1C2=CC=C(C=C2)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.