Fig. 1 · Structure
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Indomethacin-d4 Methyl Ester
Stable Isotope
Indomethacin-d4 Methyl Ester is a deuterium-labeled analog of indomethacin, a potent and nonselective inhibitor of cyclooxygenase (COX) enzymes. It exhibits significant inhibitory activity with IC50 values of 18 nM for human COX-1 and 26 nM for COX-2 in CHO cells. This compound disrupts autophagic flux by impairing lysosomal function, making it a valuable tool for studying inflammation and autophagy in various biological contexts. Its stable isotope labeling enables precise tracking and quantification in metabolic and pharmacokinetic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1217064-61-3 |
| Applications | Stable Isotope |
| Formula | C20H14D4ClNO4 |
| Molecular Weight | 375.84 |
| SMILES | O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)N2C3=CC=C(OC)C=C3C(CC(OC)=O)=C2C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.