Documents & Downloads

Topotecan-d5

Stable Isotope

Topotecan-d5 is a deuterium-labeled derivative of Topotecan, a potent inhibitor of Topoisomerase I. It exhibits notable inhibitory activity with IC50 values of 2.73±0.25 μM in U251 cells, 2.95±0.23 μM in U87 cells, and 5.46±0.41 μM and 5.95±0.24 μM in glioblastoma stem cells GSCs-U251 and GSCs-U87, respectively. This stable isotope-labeled reagent is valuable for drug metabolism studies and pharmacokinetic research, enhancing the understanding of Topotecan’s mechanism of action in cancer therapy.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
CAS Number	1133355-98-2
Applications	Stable Isotope
Formula	C₂₃H₁₈D₅N₃O₅
Molecular Weight	426.48
Synonyms	SKF 104864A-d5; NSC 609669-d5
SMILES	[2H]C([2H])([2H])C([2H])([2H])[C@@]1(C2=C(COC1=O)C(N3C(C(C(C3)=CC4=C5CN(C)C)=NC4=CC=C5O)=C2)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.