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Ixazomib-d7

Stable Isotope

Ixazomib-d7 is a deuterium-labeled derivative of Ixazomib, a selective and potent reversible proteasome inhibitor. It primarily targets the chymotrypsin-like (β5) site of the 20S proteasome, demonstrating an IC50 of 3.4 nM and a Ki of 0.93 nM. This stable isotope is valuable for tracking metabolic processes and investigating proteasome inhibition in various biological contexts, making it an essential tool in cancer research and drug development.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2177240-89-8
Applications	Stable Isotope
Formula	C₁₄H₁₂D₇BCl₂N₂O₄
Molecular Weight	368.07
Synonyms	MLN2238-d7
SMILES	[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C[C@@H](B(O)O)NC(CNC(C1=C(C=CC(Cl)=C1)Cl)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.