Fig. 1 · Structure
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Indomethacin-d4
Stable Isotope
Indomethacin-d4 is a deuterium-labeled form of Indomethacin, known as a potent, nonselective inhibitor of cyclooxygenase isoforms COX-1 and COX-2. It exhibits blood-brain barrier permeability, with reported IC50 values of 18 nM for human COX-1 and 26 nM for COX-2 in CHO cells. This compound is utilized in research to study anti-inflammatory pathways and examine the effects on autophagic flux through lysosomal disruption.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 87377-08-0 |
| Applications | Stable Isotope |
| Formula | C19H12D4ClNO4 |
| Molecular Weight | 361.81 |
| Synonyms | Indometacin-d4 |
| SMILES | O=C(O)CC1=C(C)N(C(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])=O)C3=C1C=C(OC)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.