Fig. 1 · Structure
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Megestrol acetate-d3
Stable Isotope
Megestrol acetate-d3 is a deuterium-labeled derivative of the synthetic progesterone analog, Megestrol acetate. This compound primarily acts as an appetite stimulant, making it valuable in the study of wasting syndromes, including cachexia. Additionally, Megestrol acetate has been shown to inhibit androgen receptor signaling in human benign prostatic hyperplasia (BPH) tissue and may be applicable in HIV research, as it downregulates the autophagic catabolic pathway. This stable isotope can provide insights into pharmacokinetics and metabolism of Megestrol acetate in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 162462-72-8 |
| Applications | Stable Isotope |
| Formula | C24H29D3O4 |
| Molecular Weight | 387.53 |
| SMILES | CC(O[C@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(C(C([2H])([2H])[2H])=C3)=CC(CC4)=O)C)([H])CC2)([H])CC1)C)C(C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.